HAEM5:Acute myeloid leukaemia with CBFB::MYH11 fusion: Difference between revisions
| [checked revision] | [checked revision] |
No edit summary |
No edit summary |
||
| Line 124: | Line 124: | ||
| | | | ||
| | | | ||
|}[[File:t(16;16)(p13.1;q22).png|t(16;16)(p13.1;q22)|frame| | |}[[File:t(16;16)(p13.1;q22).png|t(16;16)(p13.1;q22)|frame|alt=|left]] [[File:inv(16)(p13.1q22).png|inv(16)(p13.1q22)|frame|alt=|left]] [[File:Inv(16)(p13.1q22) karyogram and insert (8-7-18).png|inv(16)(p13.1q22). Courtesy of Karen Kundinger, Comprehensive Genetic Services, Milwaukee, WI|frame|center]]<br /> | ||
{| class="wikitable sortable" | {| class="wikitable sortable" | ||
|- | |- | ||
| Line 480: | Line 479: | ||
The <u>epidemiology/prevalence</u> of this disease is detailed below: | The <u>epidemiology/prevalence</u> of this disease is detailed below: | ||
* Approximately 5-8% of AML cases have inv(16)(p13.1q22) or t(16;16)(p13.1;q22). More common in males and younger adults. | *Approximately 5-8% of AML cases have inv(16)(p13.1q22) or t(16;16)(p13.1;q22). More common in males and younger adults. | ||
The <u>clinical features</u> of this disease are detailed below: | The <u>clinical features</u> of this disease are detailed below: | ||
| Line 490: | Line 489: | ||
The <u>sites of involvement</u> of this disease are detailed below: | The <u>sites of involvement</u> of this disease are detailed below: | ||
* Bone marrow | *Bone marrow | ||
The <u>morphologic features</u> of this disease are detailed below: | The <u>morphologic features</u> of this disease are detailed below: | ||
| Line 515: | Line 514: | ||
*populations with granulocytic differentiation positive for CD13, CD33, CD15, CD65 and MPO | *populations with granulocytic differentiation positive for CD13, CD33, CD15, CD65 and MPO | ||
*populations with monocytic differentiation, positive for CD14, CD4, CD11c, CD11b, CD11c, CD64, CD36 and lysozyme | *populations with monocytic differentiation, positive for CD14, CD4, CD11c, CD11b, CD11c, CD64, CD36 and lysozyme | ||
==Links== | ==Links== | ||