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| {{DISPLAYTITLE:Diffuse midline glioma, H3 K27-altered}} | | {{DISPLAYTITLE:Diffuse midline glioma, H3 K27-altered}} |
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| [[CNS5:Table_of_Contents|Central Nervous System Tumours(WHO Classification, 5th ed.)]] | | [[CNS5:Table_of_Contents|Central Nervous System Tumours(WHO Classification, 5th ed.)]] |
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| Linda Cooley, MD, MBA, Children's Mercy Hospital | | Linda Cooley, MD, MBA, Children's Mercy Hospital |
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| |} | | |} |
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| Put your text here and fill in the table
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| {| class="wikitable sortable"
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| |-
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| !Chromosomal Rearrangement!!Genes in Fusion (5’ or 3’ Segments)!!Pathogenic Derivative!!Prevalence
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| !Diagnostic Significance (Yes, No or Unknown)
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| !Prognostic Significance (Yes, No or Unknown)
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| !Therapeutic Significance (Yes, No or Unknown)
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| !Notes
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| |-
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| |EXAMPLE t(9;22)(q34;q11.2)||EXAMPLE 3'ABL1 / 5'BCR||EXAMPLE der(22)||EXAMPLE 20% (COSMIC)
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| EXAMPLE 30% (add reference)
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| |Yes
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| |No
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| |Yes
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| |EXAMPLE
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| The t(9;22) is diagnostic of CML in the appropriate morphology and clinical context (add reference). This fusion is responsive to targeted therapy such as Imatinib (Gleevec) (add reference).
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| |}
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| ==Individual Region Genomic Gain/Loss/LOH== | | ==Individual Region Genomic Gain/Loss/LOH== |
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| | ||gains||1q, 2 (1) | | | ||gains||1q, 2 (1) |
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| {| class="wikitable sortable"
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| !Chr #!!Gain / Loss / Amp / LOH!!Minimal Region Genomic Coordinates [Genome Build]!!Minimal Region Cytoband
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| !Diagnostic Significance (Yes, No or Unknown)
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| !Prognostic Significance (Yes, No or Unknown)
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| !Therapeutic Significance (Yes, No or Unknown)
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| !Notes
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| |EXAMPLE
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| 7
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| |EXAMPLE Loss
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| |EXAMPLE
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| chr7:1- 159,335,973 [hg38]
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| |EXAMPLE
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| chr7
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| |Yes
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| |Yes
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| |No
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| |EXAMPLE
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| Presence of monosomy 7 (or 7q deletion) is sufficient for a diagnosis of AML with MDS-related changes when there is ≥20% blasts and no prior therapy (add reference). Monosomy 7/7q deletion is associated with a poor prognosis in AML (add reference).
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| |-
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| |EXAMPLE
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| 8
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| |EXAMPLE Gain
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| |EXAMPLE
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| chr8:1-145,138,636 [hg38]
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| |EXAMPLE
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| chr8
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| |No
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| |No
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| |No
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| |EXAMPLE
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| Common recurrent secondary finding for t(8;21) (add reference).
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| |} | | |} |
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| |} | | |} |
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| Put your text here
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| {| class="wikitable sortable"
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| |-
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| !Chromosomal Pattern
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| !Diagnostic Significance (Yes, No or Unknown)
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| !Prognostic Significance (Yes, No or Unknown)
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| !Therapeutic Significance (Yes, No or Unknown)
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| !Notes
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| |-
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| |EXAMPLE
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| Co-deletion of 1p and 18q
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| |Yes
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| |No
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| |No
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| |EXAMPLE:
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| See chromosomal rearrangements table as this pattern is due to an unbalanced derivative translocation associated with oligodendroglioma (add reference).
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| |}
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| ==Gene Mutations (SNV/INDEL)== | | ==Gene Mutations (SNV/INDEL)== |
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| Prior Author(s): | | Prior Author(s): |
| <nowiki>*</nowiki>''Citation of this Page'': “Diffuse midline glioma, H3 K27-altered”. Compendium of Cancer Genome Aberrations (CCGA), Cancer Genomics Consortium (CGC), updated {{REVISIONMONTH}}/{{REVISIONDAY}}/{{REVISIONYEAR}}, <nowiki>https://ccga.io/index.php/CNS5:Diffuse midline glioma, H3 K27-altered</nowiki>. | | <nowiki>*</nowiki>''Citation of this Page'': “Diffuse midline glioma, H3 K27-altered”. Compendium of Cancer Genome Aberrations (CCGA), Cancer Genomics Consortium (CGC), updated {{REVISIONMONTH}}/{{REVISIONDAY}}/{{REVISIONYEAR}}, <nowiki>https://ccga.io/index.php/CNS5:Diffuse midline glioma, H3 K27-altered</nowiki>. |
| [[Category:CNS5]][[Category:DISEASE]][[Category:Diseases D]] | | [[Category:CNS5]] |
| | [[Category:DISEASE]] |
| | [[Category:Diseases D]] |
