CNS5:Table of Contents

Gliomas, glioneuronal tumours, and neuronal tumours (Overview Page Link)

Gliomas, glioneuronal tumours, and neuronal tumours
 Adult-type diffuse gliomas
   - Astrocytoma, IDH-mutant
   - Oligodendroglioma, IDH-mutant and 1p/19q-codeleted
   - Glioblastoma, IDH-wildtype
 Paediatric-type diffuse low-grade gliomas 
   - Diffuse astrocytoma, MYB- or MYBL1-altered
   - Angiocentric glioma
   - Polymorphous low-grade neuroepithelial tumour of the young
   - Diffuse low-grade glioma, MAPK pathway-altered 
 Paediatric-type diffuse high-grade gliomas
   - Diffuse midline glioma, H3 K27-altered
   - Diffuse hemispheric glioma, H3 G34-mutant
   - Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype
   - Infant-type hemispheric glioma
 Circumscribed astrocytic gliomas 
   - Pilocytic astrocytoma 
   - High-grade astrocytoma with piloid features
   - Pleomorphic xanthoastrocytoma
   - Subependymal giant cell astrocytoma
   - Chordoid glioma
   - Astroblastoma, MN1-altered
 Glioneuronal and neuronal tumours
   - Ganglioglioma
   - Gangliocytoma
   - Desmoplastic infantile ganglioglioma / desmoplastic infantile astrocytoma
   - Dysembryoplastic neuroepithelial tumour
   - Diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters
   - Papillary glioneuronal tumour
   - Rosette-forming glioneuronal tumour
   - Myxoid glioneuronal tumour
   - Diffuse leptomeningeal glioneuronal tumour
   - Multinodular and vacuolating neuronal tumour
   - Dysplastic cerebellar gangliocytoma (Lhermitte-Duclos disease)
   - Central neurocytoma
   - Extraventricular neurocytoma
   - Cerebellar liponeurocytoma
 Ependymal tumours
   - Supratentorial ependymoma
   - Supratentorial ependymoma, ZFTA fusion-positive 
   - Supratentorial ependymoma, YAP1 fusion-positive
   - Posterior fossa ependymoma
   - Posterior fossa group A (PFA) ependymoma
   - Posterior fossa group B (PFB) ependymoma
   - Spinal ependymoma
   - Spinal ependymoma, MYCN-amplified
   - Myxopapillary ependymoma
   - Subependymoma

Choroid plexus tumours (Overview Page Link)

   - Choroid plexus papilloma
   - Atypical choroid plexus papilloma
   - Choroid plexus carcinoma

Embryonal tumours (Overview Page Link)

Medulloblastoma
 Medulloblastomas, molecularly defined
   - Medulloblastoma, WNT-activated
   - Medulloblastoma, SHH-activated and TP53-wildtype
   - Medulloblastoma, SHH-activated and TP53-mutant
   - Medulloblastoma, non-WNT/non-SHH
 Medulloblastomas, histologically defined
   - Medulloblastoma, histologically defined

Other CNS embryonal tumours
   - Atypical teratoid/rhabdoid tumour
   - Cribriform neuroepithelial tumour
   - Embryonal tumour with multilayered rosettes
   - CNS neuroblastoma, FOXR2-activated
   - CNS tumour with BCOR internal tandem duplication
   - CNS embryonal tumour NEC/NOS

Pineal tumours (Overview Page Link)

   - Pineocytoma
   - Pineal parenchymal tumour of intermediate differentiation
   - Pineoblastoma
   - Papillary tumour of the pineal region
   - Desmoplastic myxoid tumour of the pineal region, SMARCB1-mutant

Cranial and paraspinal nerve tumours (Overview Page Link)

   - Schwannoma
   - Neurofibroma
   - Perineurioma
   - Hybrid nerve sheath tumours
   - Malignant melanotic nerve sheath tumour
   - Malignant peripheral nerve sheath tumour
   - Cauda equina neuroendocrine tumour (previously paraganglioma)

Meningioma (Overview Page Link)

   - Meningioma

Mesenchymal, non-meningothelial tumours involving the CNS (Overview Page Link)

Soft tissue tumours
 Fibroblastic and myofibroblastic tumours
   - Solitary fibrous tumour
 Vascular tumours
   - Haemangiomas and vascular malformations
   - Haemangioblastoma
 Skeletal muscle tumours
   - Rhabdomyosarcoma
 Tumours of uncertain differentiation
   - Intracranial mesenchymal tumour, FET::CREB fusion-positive
   - CIC-rearranged sarcoma
   - Primary intracranial sarcoma, DICER1-mutant
   - Ewing sarcoma

Chondro-osseous tumours
 Chondrogenic tumours
   - Mesenchymal chondrosarcoma
   - Chondrosarcoma

Notochordal tumours
   - Chordoma

Melanocytic tumours (Overview Page Link)

 Diffuse meningeal melanocytic neoplasms
   - Diffuse meningeal melanocytic neoplasms: Melanocytosis and melanomatosis
 Circumscribed meningeal melanocytic neoplasms
   - Circumscribed meningeal melanocytic neoplasms: Melanocytoma and melanoma

Haematolymphoid tumours involving the CNS (Overview Page Link)

Lymphomas
 CNS lymphomas
   - Primary diffuse large B-cell lymphoma of the CNS
   - Immunodeficiency-associated CNS lymphomas
   - Lymphomatoid granulomatosis
   - Intravascular large B-cell lymphoma
 Miscellaneous rare lymphomas in the CNS
   - MALT lymphoma of the dura
   - Other low-grade B-cell lymphomas of the CNS
   - Anaplastic large cell lymphoma (ALK+/ALK−)
   - T-cell and NK/T-cell lymphomas

Histiocytic tumours
   - Erdheim-Chester disease
   - Rosai-Dorfman disease
   - Juvenile xanthogranuloma
   - Langerhans cell histiocytosis
   - Histiocytic sarcoma

Germ cell tumours (Overview Page Link)

   - Germ cell tumours of the CNS

Tumours of the sellar region (Overview Page Link)

   - Adamantinomatous craniopharyngioma
   - Papillary craniopharyngioma
   - Pituicytoma, granular cell tumour of the sellar region, and spindle cell oncocytoma
   - Pituitary adenoma / pituitary neuroendocrine tumour
   - Pituitary blastoma

Metastases to the CNS (Overview Page Link)

   - Metastases to the brain and spinal cord parenchyma
   - Metastases to the meninges

Genetic tumour syndromes involving the CNS (Overview Page Link)

   - Neurofibromatosis type 1
   - Neurofibromatosis type 2
   - Schwannomatosis
   - Von Hippel-Lindau syndrome
   - Tuberous sclerosis
   - Li-Fraumeni syndrome
   - Cowden syndrome
   - Constitutional mismatch repair deficiency syndrome
   - Familial adenomatous polyposis 1
   - Naevoid basal cell carcinoma syndrome
   - Rhabdoid tumour predisposition syndrome
   - Carney complex
   - DICER1 syndrome
   - Familial paraganglioma syndromes
   - Melanoma-astrocytoma syndrome
   - Familial retinoblastoma
   - BAP1 tumour predisposition syndrome
   - Fanconi anaemia
   - ELP1-medulloblastoma syndrome