Compendium of Cancer Genome Aberrations

BRST5:The polygenic component of breast cancer susceptibility: Difference between revisions

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|Book
|Book
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|Breast Tumours (5th ed.)
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|Category
|Category
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|Genetic tumour syndromes of the breast
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|Family
|Family
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|Syndromes
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|Type
|Type
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|Polygenetic component of breast cancer susceptibility
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|Subtype(s)
|Subtype(s)
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|N/A
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|Acceptable
|Acceptable
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|N/A
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|Not Recommended
|Not Recommended
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|N/A
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Polygenic breast cancer risk; Common low-penetrance breast cancer alleles
Polygenic breast cancer risk; Common low-penetrance breast cancer alleles
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{| class="wikitable sortable"
'''PLEASE PUT CONTENT FROM OLD TABLE BELOW WHERE YOU WANT IT AND THEN DELETE THE OLD TABLE.'''
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!Gene; Genetic Alteration!!'''Presumed Mechanism (Tumor Suppressor Gene [TSG] / Oncogene / Other)'''!!'''Prevalence (COSMIC /  TCGA / Other)'''!!'''Concomitant Mutations'''!!'''Mutually Exclusive Mutations'''
!'''Diagnostic Significance (Yes, No or Unknown)'''
!Prognostic Significance (Yes, No or Unknown)
!Therapeutic Significance (Yes, No or Unknown)
!Notes
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|Multiple SNPs (e.g., FGFR2, MAP3K1, TOX3)
|Regulatory/epigenetic, not traditional oncogenes/TSGs
|Common, MAF >1%
|Varies
|Varies
|No
|Limited
|Yes (PRS applications
|Target gene expression changes may affect oncogenic pathways
|}
{| class="wikitable sortable"
{| class="wikitable sortable"
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