HAEM5:Classic Hodgkin lymphoma: Difference between revisions
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==Genetic Diagnostic Testing Methods== | ==Genetic Diagnostic Testing Methods== | ||
* Immunohistochemistry for CD30, CD15, PAX5, and EBV (EBER in situ hybridization) (PMID: 2477085, 6946981 | *Immunohistochemistry for CD30, CD15, PAX5, and EBV (EBER in situ hybridization) (PMID: 2477085, 6946981) | ||
*9p24.1 copy number assessment (FISH or NGS) may be used in refractory/relapsed cases to evaluate PD-L1/PD-L2 amplification for potential immunotherapy (PMID: 29394125). | |||
* 9p24.1 copy number assessment | *TR clonality assays can help exclude T-cell lymphomas in challenging differential diagnoses (PMID: 24128129). | ||
*Targeted NGS panels for NF-κB and JAK/STAT pathway mutations (PMID: 33686198) | |||
==Familial Forms== | ==Familial Forms== | ||