Breast Cancer: Recurrent Genomic Alterations: Difference between revisions
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|Gain of function | |Gain of function | ||
|164690 | |[https://omim.org/entry/164690 164690] | ||
|ABL2 | |[https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=ABL2 ABL2] | ||
|ABL2 breast | |[https://www.cbioportal.org/results/oncoprint?cancer_study_list=acbc_mskcc_2015%2Cbreast_cptac_gdc%2Cbrca_hta9_htan_2022%2Cbrca_metabric%2Cbreast_msk_2025%2Cbreast_msk_2018%2Cbrca_pareja_msk_2020%2Cbrca_mskcc_2019%2Cbreast_alpelisib_2020%2Cbrca_smc_2018%2Cbrca_bccrc_xenograft_2014%2Cbfn_duke_nus_2015%2Cbrca_bccrc%2Cbrca_broad%2Cbrca_sanger%2Cbrca_tcga_pub2015%2Cbrca_tcga%2Cbrca_tcga_pub%2Cbrca_tcga_pan_can_atlas_2018%2Cbrca_tcga_gdc%2Cbrca_jup_msk_2020%2Cbrca_mapk_hp_msk_2021%2Cmbc_msk_2021%2Cbrca_aurora_2023%2Cbrca_dfci_2020%2Cbrca_igr_2015%2Cbreast_ink4_msk_2021%2Cilc_msk_2023%2Cbrca_cptac_2020%2Cbrca_mbcproject_wagle_2017%2Cbrca_mbcproject_2022%2Cbrca_fuscc_2020&Z_SCORE_THRESHOLD=2.0&RPPA_SCORE_THRESHOLD=2.0&profileFilter=mutations%2Cstructural_variants%2Ccna%2Cgistic&case_set_id=all&gene_list=ABL2&geneset_list=%20&tab_index=tab_visualize&Action=Submit&exclude_germline_mutations=true ABL2 breast] | ||
|amplification, altered expression, sequence variants | |amplification, altered expression, sequence variants | ||
|Diseases: amplification of primarily ABL2 is seen across BC subtypes. Prognosis: poor prognostic marker in metastatic BC. ABL-targeted small molecule kinase inhibitors may be efficacious in cancers with ABL2 positive rearrangements (primarily ALL) | |Diseases: amplification of primarily ABL2 is seen across BC subtypes. Prognosis: poor prognostic marker in metastatic BC. ABL-targeted small molecule kinase inhibitors may be efficacious in cancers with ABL2 positive rearrangements (primarily ALL) | ||
|23842646; 32067942; 16740702 | |[https://pubmed.ncbi.nlm.nih.gov/23842646/ 23842646]; [https://pubmed.ncbi.nlm.nih.gov/32067942/ 32067942]; [https://pubmed.ncbi.nlm.nih.gov/16740702/ 16740702] | ||
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|''AKT1'' | |''AKT1'' | ||
|1 | |1 | ||
|Gain of function | |Gain of function | ||
|164730 | |[https://omim.org/entry/164730 164730] | ||
|AKT1 | |AKT1 | ||
|AKT1 breast | |AKT1 breast | ||