HAEM5:Adult T-cell leukaemia/lymphoma: Difference between revisions
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|''CD274 (PD-L1)'' | |||
|3′-UTR–truncating structural variants (no protein fusion) | |||
|Loss of 3′-UTR microRNA regulation → PD-L1 overexpression → immune evasion | |||
|Deletions, inversions, duplications, translocations at '''9p24.1''' disrupting 3′-UTR | |||
|Common (≈20–25% of ATLL in large cohorts) | |||
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| | |No | ||
| | |Highlights immune-evasion axis and immune checkpoint biology, but PD-1 blockade has shown harm and induced rapid progression in ATLL<ref>{{Cite journal|last=Rauch|first=Daniel A.|last2=Conlon|first2=Kevin C.|last3=Janakiram|first3=Murali|last4=Brammer|first4=Jonathan E.|last5=Harding|first5=John C.|last6=Ye|first6=B. Hilda|last7=Zang|first7=Xingxing|last8=Ren|first8=Xiaoxin|last9=Olson|first9=Sydney|date=2019-10-24|title=Rapid progression of adult T-cell leukemia/lymphoma as tumor-infiltrating Tregs after PD-1 blockade|url=https://pubmed.ncbi.nlm.nih.gov/31467059|journal=Blood|volume=134|issue=17|pages=1406–1414|doi=10.1182/blood.2019002038|issn=1528-0020|pmc=6839957|pmid=31467059}}</ref> | ||
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