HAEM5:Adult T-cell leukaemia/lymphoma: Difference between revisions
| [checked revision] | [checked revision] |
| Line 80: | Line 80: | ||
| | | | ||
|Potential for CTLA4 blockade as treatment when CD28 fusions are present | |Potential for CTLA4 blockade as treatment when CD28 fusions are present | ||
|- | |||
|''REL (c-Rel)'' | |||
|3′ truncations (no partner gene; gain-of-function) | |||
|Truncation removes negative-regulatory regions → REL upregulation/activation → NF-κB pathway activation | |||
|'''2p16.1''' 3′-end truncating rearrangements | |||
|Recurrent (~13%) | |||
| | |||
| | |||
| | |||
|} | |} | ||