Compendium of Cancer Genome Aberrations

HAEM5:B-lymphoblastic leukaemia/lymphoma with hypodiploidy: Difference between revisions

(View all pending changes)
[pending revision][pending revision]
← Older editNewer edit →
VisualWikitext
Line 137: Line 137:
==Individual Region Genomic Gain/Loss/LOH==
==Individual Region Genomic Gain/Loss/LOH==


 
Please refer to section "Characteristic Chromosomal or Other Global Mutational Patterns" below.
Put your text here and fill in the table <span style="color:#0070C0">(''Instructions: Includes aberrations not involving gene rearrangements. Details on clinical significance such as prognosis and other important information can be provided in the notes section. Can refer to CGC workgroup tables as linked on the homepage if applicable. Please include references throughout the table. Do not delete the table.'') </span>
Put your text here and fill in the table <span style="color:#0070C0">(''Instructions: Includes aberrations not involving gene rearrangements. Details on clinical significance such as prognosis and other important information can be provided in the notes section. Can refer to CGC workgroup tables as linked on the homepage if applicable. Please include references throughout the table. Do not delete the table.'') </span>
{| class="wikitable sortable"
{| class="wikitable sortable"
Line 220: Line 220:
!Clinical Relevance Details/Other Notes
!Clinical Relevance Details/Other Notes
|-
|-
|<span class="blue-text">EXAMPLE:</span>
|Near-haploid B-ALL/LBL with hypodiploidy<ref>{{Cite journal|title=BlueBooksOnline|url=https://tumourclassification.iarc.who.int/chaptercontent/63/293}}</ref>
Co-deletion of 1p and 18q
|24–31 chromosomes
|<span class="blue-text">EXAMPLE:</span> See chromosomal rearrangements table as this pattern is due to an unbalanced derivative translocation associated with oligodendroglioma (add reference).
|Rare
|<span class="blue-text">EXAMPLE:</span> Common (Oligodendroglioma)
|Associated with poor prognosis
|<span class="blue-text">EXAMPLE:</span> D, P
|No
|
|This is a very rare category, has been observed in the pediatric population with virtually no adult cases reported.  Nonrandom retention of the X chromosome plus chromosomes 8, 14, 18, and 21 are frequently observed.
|
|-
|-
|<span class="blue-text">EXAMPLE:</span>
|Low-hypodiploid B-ALL/LBL with hypodiploidy
Microsatellite instability - hypermutated
|32–39 chromosomes
|
|Rare in children, recurrent in adolescents, young adults, and adults
|<span class="blue-text">EXAMPLE:</span> Common (Endometrial carcinoma)
|Associated with poor prognosis
|<span class="blue-text">EXAMPLE:</span> P, T
|No
|
|Low-hypodiploid B-ALL/LBL is rare in children (< 1%); however, the frequency increases with age, accounting for 5% of B-ALL/LBL cases in adolescents and young adults, and > 10% of cases in adults. Nonrandom retention of two copies of chromosomes from the following: the sex chromosomes plus chromosomes 1,6, 8, 10, 14, 18, and19.  Chromosome 21 is almost always retained in two copies.
|
|-
|-
|High-hypodiploid B-ALL/LBL with hypodiploidy
|40–43 chromosomes
|
|
|
|Associated with poor prognosis
|
|No
|
|Chromosome abnormalities include whole chromosome loss, specifically one sex chromosome and often chromosomes 7, 9, and/or 13.  Also detected are structural anomalies especially dicentric chromosomes involving chromosomes 7, 9 or 12.
|
|
|}
|}


Line 309: Line 307:
|
|
|Transcription
|Transcription
|Common  
|Common
|No established significance
|No established significance
|No
|No
|
|Associated with low-hypodiploid B-ALL.
|-
|-
|<span class="blue-text">EXAMPLE:</span> ''TP53''; Variable LOF mutations
|''IKZF3''  
<br />
<br />
|<span class="blue-text">EXAMPLE:</span> Variable LOF mutations
|<span class="blue-text">EXAMPLE:</span> Variable LOF mutations
Line 321: Line 319:
|<span class="blue-text">EXAMPLE:</span> P
|<span class="blue-text">EXAMPLE:</span> P
|
|
|<span class="blue-text">EXAMPLE:</span> >90% are somatic; rare germline alterations associated with Li-Fraumeni syndrome (add reference). Denotes a poor prognosis in breast cancer.
|Associated with near-haploid B-ALL.
|-
|-
|<span class="blue-text">EXAMPLE:</span> ''BRAF''; Activating mutations
|<span class="blue-text">EXAMPLE:</span> ''BRAF''; Activating mutations
Retrieved from "https://test.ccga.io/index.php/HAEM5:B-lymphoblastic_leukaemia/lymphoma_with_hypodiploidy"