HAEM5:B-lymphoblastic leukaemia/lymphoma with hypodiploidy: Difference between revisions
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|24–31 chromosomes | |24–31 chromosomes | ||
|Rare | |Rare | ||
|Associated with poor prognosis | |Associated with poor prognosis | ||
|No | |No | ||
|This is a very rare category, has been observed in the pediatric population with virtually no adult cases reported. Nonrandom retention of the X chromosome plus chromosomes 8, 14, 18, and 21 are frequently observed. | |This is a very rare category, has been observed in the pediatric population with virtually no adult cases reported. Nonrandom retention of the X chromosome plus chromosomes 8, 14, 18, and 21 are frequently observed. | ||
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|32–39 chromosomes | |32–39 chromosomes | ||
|Rare in children, recurrent in adolescents, young adults, and adults | |Rare in children, recurrent in adolescents, young adults, and adults | ||
|Associated with poor prognosis | |Associated with poor prognosis | ||
|No | |No | ||
|Low-hypodiploid B-ALL/LBL is rare in children (< 1%); however, the frequency increases with age, accounting for 5% of B-ALL/LBL cases in adolescents and young adults, and > 10% of cases in adults. Nonrandom retention of two copies of chromosomes from the following: the sex chromosomes plus chromosomes 1,6, 8, 10, 14, 18, and19. Chromosome 21 is almost always retained in two copies. | |Low-hypodiploid B-ALL/LBL is rare in children (< 1%); however, the frequency increases with age, accounting for 5% of B-ALL/LBL cases in adolescents and young adults, and > 10% of cases in adults. Nonrandom retention of two copies of chromosomes from the following: the sex chromosomes plus chromosomes 1,6, 8, 10, 14, 18, and19. Chromosome 21 is almost always retained in two copies. | ||
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|40–43 chromosomes | |40–43 chromosomes | ||
| | | | ||
|Associated with poor prognosis | |Associated with poor prognosis | ||
|No | |No | ||
|Chromosome abnormalities include whole chromosome loss, specifically one sex chromosome and often chromosomes 7, 9, and/or 13. Also detected are structural anomalies especially dicentric chromosomes involving chromosomes 7, 9 or 12. | |Chromosome abnormalities include whole chromosome loss, specifically one sex chromosome and often chromosomes 7, 9, and/or 13. Also detected are structural anomalies especially dicentric chromosomes involving chromosomes 7, 9 or 12. | ||
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|<span class="blue-text">EXAMPLE:</span> Common (breast cancer) | |<span class="blue-text">EXAMPLE:</span> Common (breast cancer) | ||
|<span class="blue-text">EXAMPLE:</span> P | |<span class="blue-text">EXAMPLE:</span> P | ||
| | |No | ||
|Associated with near-haploid B-ALL. | |Associated with near-haploid B-ALL. | ||
|- | |- | ||