CNS5:Pleomorphic xanthoastrocytoma: Difference between revisions
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|Yes (WHO CNS5 for differential diagnosis) | |Yes (WHO CNS5 for differential diagnosis) | ||
|Absence confirms classic PXA; if present, suggests diffuse astrocytoma not PXA (PMID: 26414224) | |Absence confirms classic PXA; if present, suggests diffuse astrocytoma not PXA (PMID: 26414224) | ||
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|NTRK2, ALK | |||
|Kinase gene fusions | |||
|Oncogene | |||
|Rare | |||
|T | |||
|Yes (FDA/NCCN for fusion-positive CNS tumors, not PXA-specific) | |||
|'''Targetable by TRK/ALK inhibitors (larotrectinib, entrectinib); found chiefly in pediatric BRAF-wildtype PXAs.(PMID: 40568680)''' | |||
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