HAEM5:B-lymphoblastic leukaemia/lymphoma with high hyperdiploidy: Difference between revisions
| [pending revision] | [pending revision] |
| Line 107: | Line 107: | ||
|Chr21 | |Chr21 | ||
|''RUNX1'' | |''RUNX1'' | ||
|No established significance | |No established significance | ||
|No | |No | ||
|Chromosome 21 is universally gained in high-hyperdiploid B-ALL/LBL <ref>{{Cite journal|last=Harrison|first=Christine J.|last2=Haas|first2=Oskar|last3=Harbott|first3=Jochen|last4=Biondi|first4=Andrea|last5=Stanulla|first5=Martin|last6=Trka|first6=Jan|last7=Izraeli|first7=Shai|last8=Biology and Diagnosis Committee of International Berlin-Frankfürt-Münster study group|date=2010-10|title=Detection of prognostically relevant genetic abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: recommendations from the Biology and Diagnosis Committee of the International Berlin-Frankfürt-Münster study group|url=https://pubmed.ncbi.nlm.nih.gov/20701601|journal=British Journal of Haematology|volume=151|issue=2|pages=132–142|doi=10.1111/j.1365-2141.2010.08314.x|issn=1365-2141|pmid=20701601}}</ref>; therefore, the presence of multiple (three to five) discrete ''RUNX1'' signals seen when using ''ETV6''::''RUNX1'' FISH probes suggests the presence of high hyperdiploidy. | |Chromosome 21 is universally gained in high-hyperdiploid B-ALL/LBL <ref>{{Cite journal|last=Harrison|first=Christine J.|last2=Haas|first2=Oskar|last3=Harbott|first3=Jochen|last4=Biondi|first4=Andrea|last5=Stanulla|first5=Martin|last6=Trka|first6=Jan|last7=Izraeli|first7=Shai|last8=Biology and Diagnosis Committee of International Berlin-Frankfürt-Münster study group|date=2010-10|title=Detection of prognostically relevant genetic abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: recommendations from the Biology and Diagnosis Committee of the International Berlin-Frankfürt-Münster study group|url=https://pubmed.ncbi.nlm.nih.gov/20701601|journal=British Journal of Haematology|volume=151|issue=2|pages=132–142|doi=10.1111/j.1365-2141.2010.08314.x|issn=1365-2141|pmid=20701601}}</ref>; therefore, the presence of multiple (three to five) discrete ''RUNX1'' signals seen when using ''ETV6''::''RUNX1'' FISH probes suggests the presence of high hyperdiploidy. | ||
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|ChrX | |ChrX | ||
|None | |None | ||
|No established significance | |No established significance | ||
|No | |No | ||
|N/A | |N/A | ||
| Line 123: | Line 123: | ||
|Chr6 | |Chr6 | ||
|None | |None | ||
|No established significance | |No established significance | ||
|No | |No | ||
|N/A | |N/A | ||
| Line 131: | Line 131: | ||
|Chr14 | |Chr14 | ||
|None | |None | ||
|No established significance | |No established significance | ||
|No | |No | ||
|N/A | |N/A | ||
| Line 155: | Line 155: | ||
|Chr17 | |Chr17 | ||
|None | |None | ||
|''See prognosis section for +4 above | |''See prognosis section for +4 above'' | ||
|No | |No | ||
|N/A | |N/A | ||
| Line 163: | Line 163: | ||
|Chr10 | |Chr10 | ||
|None | |None | ||
|''See prognosis section for +4 above | |''See prognosis section for +4 above'' | ||
|No | |No | ||
|N/A | |N/A | ||
| Line 171: | Line 171: | ||
|Chr8 | |Chr8 | ||
|None | |None | ||
|No established significance | |No established significance | ||
|No | |No | ||
|N/A | |N/A | ||