HAEM5:B lymphoblastic leukaemia/lymphoma with IGH::IL3 fusion: Difference between revisions

The t(5;14)(q31.1;q32) translocation can be detected by karyotyping or FISH; however, cases with a low blast count or a cytogenetically cryptic rearrangement may require Next-generation sequencing assays to increase sensitivity<ref>{{Cite journal|last=Guenzel|first=Adam J.|last2=Smadbeck|first2=James B.|last3=Golden|first3=Crystal L.|last4=Williamson|first4=Cynthia M.|last5=Benevides Demasi|first5=Jonna C.|last6=Vasmatzis|first6=George|last7=Pearce|first7=Kathryn E.|last8=Olteanu|first8=Horatiu|last9=Xu|first9=Xinjie|date=2021-08|title=Clinical utility of next generation sequencing to detect IGH/IL3 rearrangements [t(5;14)(q31.1;q32.1)] in B-lymphoblastic leukemia/lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/33991782|journal=Annals of Diagnostic Pathology|volume=53|pages=151761|doi=10.1016/j.anndiagpath.2021.151761|issn=1532-8198|pmid=33991782}}</ref><ref>{{Cite journal|last=Fournier|first=Benjamin|last2=Balducci|first2=Estelle|last3=Duployez|first3=Nicolas|last4=Clappier|first4=Emmanuelle|last5=Cuccuini|first5=Wendy|last6=Arfeuille|first6=Chloé|last7=Caye-Eude|first7=Aurélie|last8=Delabesse|first8=Eric|last9=Bottollier-Lemallaz Colomb|first9=Elodie|date=2019|title=B-ALL With t(5;14)(q31;q32); IGH-IL3 Rearrangement and Eosinophilia: A Comprehensive Analysis of a Peculiar IGH-Rearranged B-ALL|url=https://pubmed.ncbi.nlm.nih.gov/31921638|journal=Frontiers in Oncology|volume=9|pages=1374|doi=10.3389/fonc.2019.01374|issn=2234-943X|pmc=6914849|pmid=31921638}}</ref>.