HAEM5:Systemic EBV-positive T-cell lymphoma of childhood: Difference between revisions
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** The WHO 5th edition and International Consensus Classification note that cytogenetic abnormalities favor a diagnosis of SEBVTCL over EBV-positive nonfamilial HLH.<ref name=":3" /><ref name=":0" /> | ** The WHO 5th edition and International Consensus Classification note that cytogenetic abnormalities favor a diagnosis of SEBVTCL over EBV-positive nonfamilial HLH.<ref name=":3" /><ref name=":0" /> | ||
** Primary/familial EBV-positive HLH can be excluded by family history and genetic analysis<ref name=":10" /> | ** Primary/familial EBV-positive HLH can be excluded by family history and genetic analysis<ref name=":10" /> | ||
* TCR-gene rearrangements can be detected via PCR or NGS methods. Cytogenetic abnormalities can be detected with karyotype and | * TCR-gene rearrangements can be detected via PCR or NGS methods. Cytogenetic abnormalities can be detected with karyotype and chromosome microarray (CMA). | ||
== Familial Forms == | == Familial Forms == | ||