STBT5:Solitary fibrous tumour: Difference between revisions
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{{Under Construction}} | {{Under Construction}} | ||
==Primary Author(s)*== | ==Primary Author(s)*== | ||
Reba Daniel and Shashi Shetty | Yiting Li*, Reba Daniel and Shashi Shetty | ||
==WHO Classification of Disease== | ==WHO Classification of Disease== | ||
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|Not Recommended | |Not Recommended | ||
| | |Haemangiopericytoma; Giant cell angiofibroma; Benign solitary fibrous tumour | ||
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# '''Fusion testing''' | # '''Fusion testing''' | ||
#* Next generation sequencing (NGS) using mRNA targeting the fusion | #* Next generation sequencing (NGS) using mRNA targeting the fusion | ||
#* Dual color dual fusion probe targeting both genes<ref>{{Cite journal|last=Kouba|first=Erik|last2=Simper|first2=Novae B.|last3=Chen|first3=Shaoxiong|last4=Williamson|first4=Sean R.|last5=Grignon|first5=David J.|last6=Eble|first6=John N.|last7=MacLennan|first7=Gregory T.|last8=Montironi|first8=Rodolfo|last9=Lopez-Beltran|first9=Antonio|date=2017-06-01|title=Solitary fibrous tumour of the genitourinary tract: a clinicopathological study of 11 cases and their association with the NAB2-STAT6 fusion gene|url=https://jcp.bmj.com/content/70/6/508|journal=Journal of Clinical Pathology|language=en|volume=70|issue=6|pages=508–514|doi=10.1136/jclinpath-2016-204088|issn=0021-9746|pmid=27802414}}</ref> | #* Dual color dual fusion fluorescence in situ hybridization (FISH) probe targeting both genes<ref>{{Cite journal|last=Kouba|first=Erik|last2=Simper|first2=Novae B.|last3=Chen|first3=Shaoxiong|last4=Williamson|first4=Sean R.|last5=Grignon|first5=David J.|last6=Eble|first6=John N.|last7=MacLennan|first7=Gregory T.|last8=Montironi|first8=Rodolfo|last9=Lopez-Beltran|first9=Antonio|date=2017-06-01|title=Solitary fibrous tumour of the genitourinary tract: a clinicopathological study of 11 cases and their association with the NAB2-STAT6 fusion gene|url=https://jcp.bmj.com/content/70/6/508|journal=Journal of Clinical Pathology|language=en|volume=70|issue=6|pages=508–514|doi=10.1136/jclinpath-2016-204088|issn=0021-9746|pmid=27802414}}</ref> | ||
#** a direct confirmation for ''NAB2::STAT6'' fusion | #** a direct confirmation for ''NAB2::STAT6'' fusion | ||
# '''Breakpoint detection''' | # '''Breakpoint detection''' | ||
#* Breakpoint fluorescence in situ hybridization (FISH) probe for ''STAT6'' | #* Breakpoint fluorescence in situ hybridization (FISH) probe for ''STAT6'' | ||
==Familial Forms== | ==Familial Forms== | ||
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==Additional Information== | ==Additional Information== | ||
'''Immunohistochemistry testing''' | |||
* STAT6 (signal transducer and activator of transcription 6) immunostain | |||
** nuclear staining | |||
** high sensitivity and specificity<ref>{{Cite journal|last=Doyle|first=Leona A|last2=Vivero|first2=Marina|last3=Fletcher|first3=Christopher DM|last4=Mertens|first4=Fredrik|last5=Hornick|first5=Jason L|date=2014-03|title=Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics|url=https://linkinghub.elsevier.com/retrieve/pii/S0893395222018294|journal=Modern Pathology|language=en|volume=27|issue=3|pages=390–395|doi=10.1038/modpathol.2013.164}}</ref> | |||
'''Target therapy''' | |||
* Antiangiogenic therapy showed activity in advanced and progressive SFT<ref>{{Cite journal|last=de Bernardi|first=Axel|last2=Dufresne|first2=Armelle|last3=Mishellany|first3=Florence|last4=Blay|first4=Jean-Yves|last5=Ray-Coquard|first5=Isabelle|last6=Brahmi|first6=Mehdi|date=2022-02-20|title=Novel Therapeutic Options for Solitary Fibrous Tumor: Antiangiogenic Therapy and Beyond|url=https://www.mdpi.com/2072-6694/14/4/1064|journal=Cancers|language=en|volume=14|issue=4|pages=1064|doi=10.3390/cancers14041064|issn=2072-6694}}</ref> | |||
==Links== | ==Links== | ||
None | None | ||