Archived:Clear cell renal cell carcinoma

Contributors

Daynna Wolff PhD FACMG

Tumor Type

Renal Cell Carcinoma

Tumor Classification

Clear Cell RCC

This tumor type accounts for 70-75% of all renal cell carcinoma cases (citation needed).

Description

Malignant epithelial cells with clear cytoplasm and a compact-alveolar (nested) or acinar growth pattern interspersed with intricate, arborizing vasculature. A variable proportion of cells with granular eosinophilic cytoplasm may be present. Infrequently, clear cell renal cell carcinoma has a distinct tubular pattern and rarely a pseudopapillary architecture is focally present."

IHC Markers

Positive: vimentin, CD10, RCC, PAX2, PAX8, CA-IX, EMA

Negative: CK7, CD117, AMACR, E-cadherin

Genomic Gain/Loss/LOH

chr1 Loss: 1p

chr2

chr3 Loss: 3p (3p21, 3p25 and/or 3p13-p14)

chr4 Loss: 4q

chr5 Gain: 5q

chr6

chr7

chr8 Loss: 8p

chr9 Loss: 9p, 9q

chr10

chr11

chr12

chr13

chr14 Loss: 14q

chr15

chr16

chr17

chr18

chr19

chr20

chr21

chr22

X

Y

Rearrangements

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Mutations (SNV/INDEL)

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Epigenomics (methylation)

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Main Pathways Involved

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Clinical Significance

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Diagnosis

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Prognosis

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Therapeutics

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Familial Forms

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