Gene:MYH11: Difference between revisions
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inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11 | inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11 | ||
The CBFβ–MYH11 fusion protein exerts a dominant negative function by | The CBFβ–MYH11 fusion gene encodes a protein that exerts a dominant negative function by binding to the transcription factor encoded by RUNX1. The fusion protein encoded by CBFβ–MYH11 competes (10-fold increased binding affinity) with normal CBFbeta protein for free Runx1 protein, and leading to lowered and altered transcription of myeloid genes normally controlled by CBFbeta and Runx1 transcription factors [2]. | ||
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