Tumours of Haematopoietic and Lymphoid Tissues: Difference between revisions

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== Myeloproliferative Neoplasms (MPN) ==
==Myeloproliferative Neoplasms (MPN)==
 
*[[Chronic Myeloid Leukemia (CML), BCR-ABL1 Positive]]
*[[Chronic Myeloid Leukemia (CML), BCR-ABL1 Positive]]
*[[Chronic Neutrophilic Leukemia (CNL)]]
*[[Chronic Neutrophilic Leukemia (CNL)]]
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*[[Myeloproliferative Neoplasm (MPN), Unclassifiable]]
*[[Myeloproliferative Neoplasm (MPN), Unclassifiable]]


== Mastocytosis ==
==Mastocytosis==
 
*[[Cutaneous Mastocytosis]]
*[[Cutaneous Mastocytosis]]
*[[Systemic Mastocytosis]]
*[[Systemic Mastocytosis]]
*[[Mast Cell Sarcoma]]
*[[Mast Cell Sarcoma]]


== Myeloid/Lymphoid Neoplasms with Eosinophilia and Rearrangement of PDGFRA, PDGFRB or FGFR1, or with PCM1-JAK2 ==
==Myeloid/Lymphoid Neoplasms with Eosinophilia and Rearrangement of PDGFRA, PDGFRB or FGFR1, or with PCM1-JAK2==
 
*[[Myeloid/Lymphoid Neoplasms with PDGFRA Rearrangement]]
*[[Myeloid/Lymphoid Neoplasms with PDGFRA Rearrangement]]
*[[Myeloid/Lymphoid Neoplasms with PDGFRB Rearrangement]]
*[[Myeloid/Lymphoid Neoplasms with PDGFRB Rearrangement]]
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*[[Myeloid/Lymphoid Neoplasms with PCM1-JAK2]]
*[[Myeloid/Lymphoid Neoplasms with PCM1-JAK2]]


== Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN) ==
==Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN)==
 
*[[Chronic Myelomonocytic Leukemia (CMML)]]
*[[Chronic Myelomonocytic Leukemia (CMML)]]
*[[Atypical Chronic Myeloid Leukemia (aCML), BCR-ABL1 Negative]]
*[[Atypical Chronic Myeloid Leukemia (aCML), BCR-ABL1 Negative]]
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*[[Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN), Unclassifiable|MDS/MPN, Unclassifiable]]
*[[Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN), Unclassifiable|MDS/MPN, Unclassifiable]]


== Myelodysplastic Syndromes (MDS) ==
==Myelodysplastic Syndromes (MDS)==
 
*[[Myelodysplastic Syndrome (MDS) with Single Lineage Dysplasia|MDS with Single Lineage Dysplasia]]
*[[Myelodysplastic Syndrome (MDS) with Single Lineage Dysplasia|MDS with Single Lineage Dysplasia]]
*[[Myelodysplastic Syndrome with Ring Sideroblasts (MDS-RS)|MDS with Ring Sideroblasts (MDS-RS)]]
*[[Myelodysplastic Syndrome with Ring Sideroblasts (MDS-RS)|MDS with Ring Sideroblasts (MDS-RS)]]
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*[[Refractory Cytopenia of Childhood]]
*[[Refractory Cytopenia of Childhood]]


== Myeloid Neoplasms with Germline Predisposition ==
==Myeloid Neoplasms with Germline Predisposition==


*[[Acute Myeloid Leukaemia with Germline CEBPA Mutation]]
*[[Acute Myeloid Leukaemia with Germline CEBPA Mutation]]
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*[[Myeloid Neoplasms with Germline GATA2 Mutation]]
*[[Myeloid Neoplasms with Germline GATA2 Mutation]]


== Acute Myeloid Leukemia (AML) and Related Precursor Neoplasms ==
==Acute Myeloid Leukemia (AML) and Related Precursor Neoplasms==
 
*[[Acute Myeloid Leukemia (AML) with Recurrent Genetic Abnormalities|AML with Recurrent Genetic Abnormalities]]
*[[Acute Myeloid Leukemia (AML) with Recurrent Genetic Abnormalities|AML with Recurrent Genetic Abnormalities]]


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   - [[Myeloid Leukemia Associated with Down Syndrome]]
   - [[Myeloid Leukemia Associated with Down Syndrome]]


== Blastic Plasmacytoid Dendritic Cell Neoplasm ==
==Blastic Plasmacytoid Dendritic Cell Neoplasm==
 
*[[Blastic Plasmacytoid Dendritic Cell Neoplasm]]
*[[Blastic Plasmacytoid Dendritic Cell Neoplasm]]


== Acute Leukemias of Ambiguous Lineage (MPAL) ==
==Acute Leukemias of Ambiguous Lineage (MPAL)==
 
*[[Acute Leukemias of Ambiguous Lineage]]
*[[Acute Leukemias of Ambiguous Lineage]]


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   - [[Acute Leukemias of Ambiguous Lineage, Not Otherwise Specified (NOS)]]
   - [[Acute Leukemias of Ambiguous Lineage, Not Otherwise Specified (NOS)]]


== Precursor Lymphoid Neoplasms (B-ALL, T-ALL) ==
==Precursor Lymphoid Neoplasms (B-ALL, T-ALL)==
 
*[[B-Lymphoblastic Leukemia/Lymphoma with Recurrent Genetic Abnormalities|B-Lymphoblastic Leukemia/Lymphoma (B-ALL) with Recurrent Genetic Abnormalities]]
*[[B-Lymphoblastic Leukemia/Lymphoma with Recurrent Genetic Abnormalities|B-Lymphoblastic Leukemia/Lymphoma (B-ALL) with Recurrent Genetic Abnormalities]]


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   - [[NK-Lymphoblastic Leukemia/Lymphoma]]
   - [[NK-Lymphoblastic Leukemia/Lymphoma]]


== Mature B-Cell Neoplasms (CLL, Plasma Cell Neoplasms, Non-Hodgkin B-cell Lymphomas) ==
==Mature B-Cell Neoplasms (CLL, Plasma Cell Neoplasms, Non-Hodgkin B-cell Lymphomas)==
 
*[[Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma]]
*[[Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma]]
   - [[Monoclonal B-cell Lymphocytosis]]
   - [[Monoclonal B-cell Lymphocytosis]]


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*[[Splenic B-cell Lymphoma/Leukemia, Unclassifiable]]
*[[Splenic B-cell Lymphoma/Leukemia, Unclassifiable]]
   - [[Splenic Diffuse Red Pulp Small B-cell Lymphoma]]
   - [[Splenic Diffuse Red Pulp Small B-cell Lymphoma]]
   - [[Hairy Cell Leukemia Variant]]
   - [[Hairy Cell Leukemia Variant]]


*[[Lymphoplasmacytic Lymphoma]]
*[[Lymphoplasmacytic Lymphoma]]
   - [[Waldenstrom Macroglobulinemia]]
   - [[Waldenstrom Macroglobulinemia]]


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*[[Heavy Chain Diseases]]
*[[Heavy Chain Diseases]]
   - [[Mu Heavy Chain Disease]]
   - [[Mu Heavy Chain Disease]]
   - [[Gamma Heavy Chain Disease]]
   - [[Gamma Heavy Chain Disease]]
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*[[Plasma Cell Neoplasms]]
*[[Plasma Cell Neoplasms]]
   - [[Non-IgM Monoclonal Gammopathy of Undetermined Significance]]
   - [[Non-IgM Monoclonal Gammopathy of Undetermined Significance]]
   - [[Plasma Cell Myeloma]]
   - [[Plasma Cell Myeloma]]
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*[[Nodal Marginal Zone Lymphoma]]
*[[Nodal Marginal Zone Lymphoma]]
   - [[Paediatric Nodal Marginal Zone Lymphoma]]
   - [[Paediatric Nodal Marginal Zone Lymphoma]]


*[[Follicular Lymphoma]]
*[[Follicular Lymphoma]]
   - [[Testicular Follicular Lymphoma]]
   - [[Testicular Follicular Lymphoma]]
   - [[In Situ Follicular Neoplasia]]
   - [[In Situ Follicular Neoplasia]]
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*[[Mantle Cell Lymphoma]]
*[[Mantle Cell Lymphoma]]
   - [[Leukemic Non-Nodal Mantle Cell Lymphoma]]
   - [[Leukemic Non-Nodal Mantle Cell Lymphoma]]
   - [[In Situ Mantle Cell Neoplasia]]
   - [[In Situ Mantle Cell Neoplasia]]
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*[[Diffuse Large B-cell Lymphoma Associated with Chronic Inflammation]]
*[[Diffuse Large B-cell Lymphoma Associated with Chronic Inflammation]]
   - [[Fibrin-Associated Diffuse Large B-cell Lymphoma]]
   - [[Fibrin-Associated Diffuse Large B-cell Lymphoma]]


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*[[HHV8-Associated Lymphoproliferative Disorders]]
*[[HHV8-Associated Lymphoproliferative Disorders]]
   - [[Multicentric Castleman Disease]]
   - [[Multicentric Castleman Disease]]
   - [[HHV8-Positive Diffuse Large B-cell Lymphoma, Not Otherwise Specified (NOS)]]
   - [[HHV8-Positive Diffuse Large B-cell Lymphoma, Not Otherwise Specified (NOS)]]
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*[[High-Grade B-cell Lymphoma]]
*[[High-Grade B-cell Lymphoma]]
   - [[High-Grade B-cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements]]
   - [[High-Grade B-cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements]]
   - [[High-Grade B-cell Lymphoma, Not Otherwise Specified (NOS)]]
   - [[High-Grade B-cell Lymphoma, Not Otherwise Specified (NOS)]]
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*[[B-cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-cell Lymphoma and Classic Hodgkin Lymphoma]]
*[[B-cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-cell Lymphoma and Classic Hodgkin Lymphoma]]


== Mature T- and NK-cell Neoplasms ==
==Mature T- and NK-cell Neoplasms==
 
*[[T-cell Prolymphocytic Leukemia]]
*[[T-cell Prolymphocytic Leukemia]]


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*[[EBV-Positive T-cell and NK-cell Lymphoproliferative Diseases of Childhood]]
*[[EBV-Positive T-cell and NK-cell Lymphoproliferative Diseases of Childhood]]
   - [[Systemic EBV-Positive T-cell Lymphoma of Childhood]]
   - [[Systemic EBV-Positive T-cell Lymphoma of Childhood]]
   - [[Chronic Active EBV Infection of T- and NK-cell Type, Systemic Form]]
   - [[Chronic Active EBV Infection of T- and NK-cell Type, Systemic Form]]
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*[[Intestinal T-cell Lymphoma]]
*[[Intestinal T-cell Lymphoma]]
   - [[Enteropathy-Associated T-cell Lymphoma]]
   - [[Enteropathy-Associated T-cell Lymphoma]]
   - [[Monomorphic Epitheliotropic Intestinal T-cell Lymphoma]]
   - [[Monomorphic Epitheliotropic Intestinal T-cell Lymphoma]]
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*[[Primary Cutaneous CD30 Positive T-cell Lymphoproliferative Disorders]]
*[[Primary Cutaneous CD30 Positive T-cell Lymphoproliferative Disorders]]
   - [[Lymphomatoid Papulosis]]
   - [[Lymphomatoid Papulosis]]
   - [[Primary Cutaneous Anaplastic Large Cell Lymphoma]]
   - [[Primary Cutaneous Anaplastic Large Cell Lymphoma]]


*[[Primary Cutaneous Peripheral T-cell Lymphomas, Rare Subtypes]]
*[[Primary Cutaneous Peripheral T-cell Lymphomas, Rare Subtypes]]
   - [[Primary Cutaneous Gamma Delta T-cell Lymphoma]]
   - [[Primary Cutaneous Gamma Delta T-cell Lymphoma]]
   - [[Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-cell Lymphoma]]
   - [[Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-cell Lymphoma]]
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*[[Angioimmunoblastic T-cell Lymphoma and Other Nodal Lymphomas of T Follicular Helper Cell Origin]]
*[[Angioimmunoblastic T-cell Lymphoma and Other Nodal Lymphomas of T Follicular Helper Cell Origin]]
   - [[Angioimmunoblastic T-cell Lymphoma]]
   - [[Angioimmunoblastic T-cell Lymphoma]]
   - [[Follicular T-cell Lymphoma]]
   - [[Follicular T-cell Lymphoma]]
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*[[Breast Implant-Associated Anaplastic Large Cell Lymphoma]]
*[[Breast Implant-Associated Anaplastic Large Cell Lymphoma]]


== Hodgkin Lymphomas==  
==Hodgkin Lymphomas==  
 
*[[Nodular Lymphocyte Predominant Hodgkin Lymphoma]]
*[[Nodular Lymphocyte Predominant Hodgkin Lymphoma]]


*[[Classic Hodgkin Lymphoma]]
*[[Classic Hodgkin Lymphoma]]
   - [[Nodular Sclerosis Classic Hodgkin Lymphoma]]
   - [[Nodular Sclerosis Classic Hodgkin Lymphoma]]
   - [[Lymphocyte-Rich Classic Hodgkin Lymphoma]]
   - [[Lymphocyte-Rich Classic Hodgkin Lymphoma]]
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   - [[Lymphocyte-Depleted Classic Hodgkin Lymphoma]]
   - [[Lymphocyte-Depleted Classic Hodgkin Lymphoma]]


== Immunodeficiency-Associated Lymphoproliferative Disorders==  
==Immunodeficiency-Associated Lymphoproliferative Disorders==  
 
*[[Lymphomas Associated with HIV Infection]]
*[[Lymphomas Associated with HIV Infection]]


*[[Post-Transplant Lymphoproliferative Disorders]]
*[[Post-Transplant Lymphoproliferative Disorders]]
   - [[Non-Destructive Post-Transplant Lymphoproliferative Disorders]]
   - [[Non-Destructive Post-Transplant Lymphoproliferative Disorders]]
   - [[Polymorphic Post-Transplant Lymphoproliferative Disorders]]
   - [[Polymorphic Post-Transplant Lymphoproliferative Disorders]]
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*[[Other Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders]]
*[[Other Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders]]


== Histiocytic and Dendritic Cell Neoplasms ==  
==Histiocytic and Dendritic Cell Neoplasms==  
 
*[[Histiocytic Sarcoma]]
*[[Histiocytic Sarcoma]]


*[[Tumors Derived From Langerhans Cells]]
*[[Tumors Derived From Langerhans Cells]]
   - [[Langerhans Cell Histiocytosis]]
   - [[Langerhans Cell Histiocytosis]]
   - [[Langerhans Cell Sarcoma]]
   - [[Langerhans Cell Sarcoma]]
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*[[Follicular Dendritic Cell Sarcoma]]
*[[Follicular Dendritic Cell Sarcoma]]
   - [[Inflammatory Pseudotumor-Like Follicular/Fibroblastic Dendritic Cell Sarcoma]]
   - [[Inflammatory Pseudotumor-Like Follicular/Fibroblastic Dendritic Cell Sarcoma]]


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NOTES
NOTES
The hierarchical tumour classification structure displayed on this page is reproduced from the WHO Classification of Tumours with permission from the copyright holder, ©International Agency for Research on Cancer.
The hierarchical tumour classification structure displayed on this page is reproduced from the [https://tumourclassification.iarc.who.int/welcome/ WHO Classification of Tumours] with permission from the copyright holder, ©International Agency for Research on Cancer.

Revision as of 09:11, 3 March 2021

Myeloproliferative Neoplasms (MPN)

Mastocytosis

Myeloid/Lymphoid Neoplasms with Eosinophilia and Rearrangement of PDGFRA, PDGFRB or FGFR1, or with PCM1-JAK2

Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN)

Myelodysplastic Syndromes (MDS)

Myeloid Neoplasms with Germline Predisposition

Acute Myeloid Leukemia (AML) and Related Precursor Neoplasms

  - AML with t(8;21)(q22;q22.1); RUNX1-RUNX1T1
  - AML with with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11
  - Acute Promyelocytic Leukemia (APL) with PML-RARA
  - AML with t(9;11)(p21.3;q23.3); KMT2A-MLLT3
  - AML with t(6;9)(p23;q34.1); DEK-NUP214
  - AML with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2);GATA2, MECOM
  - AML Megakaryoblastic with t(1;22)(p13.3;q13.1);RBM15-MKL1
  - AML with BCR-ABL1
  - AML with Mutated NPM1
  - AML with Biallelic Mutations of CEBPA
  - AML with Mutated RUNX1
  - AML with Minimal Differentiation
  - AML without Maturation
  - AML with Maturation
  - Acute Myelomonocytic Leukemia
  - Acute Monoblastic and Monocytic Leukemia
  - Pure Erythroid Leukemia
  - Acute Megakaryoblastic Leukemia (AMKL)
  - Acute Basophilic Leukemia
  - Acute Panmyelosis with Myelofibrosis
  - Transient Abnormal Myelopoiesis (TAM) Associated with Down Syndrome
  - Myeloid Leukemia Associated with Down Syndrome

Blastic Plasmacytoid Dendritic Cell Neoplasm

Acute Leukemias of Ambiguous Lineage (MPAL)

  - Acute Undifferentiated Leukemia
  - Mixed Phenotype Acute Leukemia (MPAL) with t(9;22)(q34.1;q11.2); BCR-ABL1
  - Mixed Phenotype Acute Leukemia (MPAL) with t(v;11q23.3); KMT2A Rearranged
  - Mixed Phenotype Acute Leukemia (MPAL), B/Myeloid, Not Otherwise Specified
  - Mixed Phenotype Acute Leukemia (MPAL), T/Myeloid, Not Otherwise Specified
  - Mixed-Phenotype Acute Leukemia, Not Otherwise Specified (NOS), Rare Types
  - Acute Leukemias of Ambiguous Lineage, Not Otherwise Specified (NOS)

Precursor Lymphoid Neoplasms (B-ALL, T-ALL)

  - B-ALL with t(9;22)(q34.1;q11.2); BCR-ABL1
  - B-ALL with t(v;11q23.3); KMT2A-Rearranged
  - B-ALL with t(12;21)(p13.2;q22.1); ETV6-RUNX1
  - B-ALL with Hyperdiploidy
  - B-ALL with Hypodiploidy
  - B-ALL with t(5;14)(q31.1;q32.1); IGH/IL3
  - B-ALL with t(1;19)(q23;p13.3); TCF3-PBX1
  - B-ALL, BCR-ABL1-Like
  - B-ALL with iAMP21
  - B-ALL, Not Otherwise Specified
  - Early T-Cell Precursor Lymphoblastic Leukemia
  - NK-Lymphoblastic Leukemia/Lymphoma

Mature B-Cell Neoplasms (CLL, Plasma Cell Neoplasms, Non-Hodgkin B-cell Lymphomas)

  - Monoclonal B-cell Lymphocytosis
  - Splenic Diffuse Red Pulp Small B-cell Lymphoma
  - Hairy Cell Leukemia Variant
  - Waldenstrom Macroglobulinemia
  - Mu Heavy Chain Disease
  - Gamma Heavy Chain Disease
  - Alpha Heavy Chain Disease
  - Non-IgM Monoclonal Gammopathy of Undetermined Significance
  - Plasma Cell Myeloma
  - Plasma Cell Myeloma Variants
  - Plasmacytoma
  - Monoclonal Immunoglobulin Deposition Diseases
        - Primary Amyloidosis
        - Light Chain and Heavy Chain Deposition Disease
  - Plasma Cell Neoplasms with Associated Paraneoplastic Syndrome
        - POEMS Syndrome
        - TEMPI Syndrome
  - Paediatric Nodal Marginal Zone Lymphoma
  - Testicular Follicular Lymphoma
  - In Situ Follicular Neoplasia
  - Duodenal-Type Follicular Lymphoma
  - Leukemic Non-Nodal Mantle Cell Lymphoma
  - In Situ Mantle Cell Neoplasia
  - Fibrin-Associated Diffuse Large B-cell Lymphoma
  - Multicentric Castleman Disease
  - HHV8-Positive Diffuse Large B-cell Lymphoma, Not Otherwise Specified (NOS)
  - HHV8-Positive Germinotropic Lymphoproliferative Disorder
  - High-Grade B-cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements
  - High-Grade B-cell Lymphoma, Not Otherwise Specified (NOS)

Mature T- and NK-cell Neoplasms

  - Systemic EBV-Positive T-cell Lymphoma of Childhood
  - Chronic Active EBV Infection of T- and NK-cell Type, Systemic Form
  - Hydroa Vacciniforme-Like Lymphoproliferative Disorder
  - Severe Mosquito Bite Allergy
  - Enteropathy-Associated T-cell Lymphoma
  - Monomorphic Epitheliotropic Intestinal T-cell Lymphoma
  - Intestinal T-cell Lymphoma, Not Otherwise Specified (NOS)
  - Indolent T-cell Lymphoproliferative Disorder of the Gastrointestinal Tract
  - Lymphomatoid Papulosis
  - Primary Cutaneous Anaplastic Large Cell Lymphoma
  - Primary Cutaneous Gamma Delta T-cell Lymphoma
  - Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-cell Lymphoma
  - Primary Cutaneous Acral CD8+ T-cell Lymphoma
  - Primary Cutaneous CD4+ Small/Medium T-cell Lymphoproliferative Disorder
  - Angioimmunoblastic T-cell Lymphoma
  - Follicular T-cell Lymphoma
  - Nodal Peripheral T-cell Lymphoma with T Follicular Helper Phenotype

Hodgkin Lymphomas

  - Nodular Sclerosis Classic Hodgkin Lymphoma
  - Lymphocyte-Rich Classic Hodgkin Lymphoma
  - Mixed Cellularity Classic Hodgkin Lymphoma
  - Lymphocyte-Depleted Classic Hodgkin Lymphoma

Immunodeficiency-Associated Lymphoproliferative Disorders

  - Non-Destructive Post-Transplant Lymphoproliferative Disorders
  - Polymorphic Post-Transplant Lymphoproliferative Disorders
  - Monomorphic Post-Transplant Lymphoproliferative Disorders (B- and T/NK-cell Types)
        - Monomorphic B-cell PTLD
        - Monomorphic T/NK-cell PTLD
  - Classical Hodgkin Lymphoma Post-Transplant Lymphoproliferative Disorder

Histiocytic and Dendritic Cell Neoplasms

  - Langerhans Cell Histiocytosis
  - Langerhans Cell Sarcoma
  - Inflammatory Pseudotumor-Like Follicular/Fibroblastic Dendritic Cell Sarcoma

NOTES The hierarchical tumour classification structure displayed on this page is reproduced from the WHO Classification of Tumours with permission from the copyright holder, ©International Agency for Research on Cancer.