Haematolymphoid Tumours 5th ed. (HAEM5) Table of Contents

Myeloid proliferations and neoplasms

Myeloid precursor lesions
 Clonal Haematopoiesis
   - HAEM5:Clonal haematopoiesis  Incomplete 
   - HAEM5:Clonal cytopenias of undetermined significance  Incomplete 

Myeloproliferative neoplasms
 Myeloproliferative neoplasms
   - HAEM5:Chronic myeloid leukaemia  Incomplete 
   - HAEM5:Chronic neutrophilic leukaemia  Incomplete 
   - HAEM5:Chronic eosinophilic leukaemia  Complete 
   - HAEM5:Polycythaemia vera  Incomplete 
   - HAEM5:Essential thrombocythaemia  Incomplete 
   - HAEM5:Primary myelofibrosis  Incomplete 
   - HAEM5:Juvenile myelomonocytic leukaemia  Incomplete 
   - HAEM5:Myeloproliferative neoplasm, NOS  Incomplete 

Mastocytosis
   - HAEM5:Cutaneous mastocytosis  Incomplete 
   - HAEM5:Systemic mastocytosis  Incomplete 
   - HAEM5:Mast cell sarcoma  Incomplete 

Myelodysplastic neoplasms
 Myelodysplastic neoplasms, with defining genetic abnormalities
   - HAEM5:Myelodysplastic neoplasm with low blasts and 5q deletion  Incomplete 
   - HAEM5:Myelodysplastic neoplasm with low blasts and SF3B1 mutation  Incomplete 
   - HAEM5:Myelodysplastic neoplasm with biallelic TP53 inactivation  Complete 
 Myelodysplastic neoplasms, morphologically defined
   - HAEM5:Myelodysplastic neoplasm with low blasts  Incomplete 
   - HAEM5:Myelodysplastic neoplasm, hypoplastic  Incomplete 
   - HAEM5:Myelodysplastic neoplasm with increased blasts  Incomplete 
 Myelodysplastic neoplasms of childhood
   - HAEM5:Childhood myelodysplastic neoplasm with low blasts  Incomplete 
   - HAEM5:Childhood myelodysplastic neoplasm with increased blasts  Incomplete 

Myelodysplastic/myeloproliferative neoplasms
   - HAEM5:Chronic myelomonocytic leukaemia  Incomplete 
   - HAEM5:Myelodysplastic/myeloproliferative neoplasm with neutrophilia  Incomplete 
   - HAEM5:Myelodysplastic/myeloproliferative neoplasm with SF3B1 mutation and thrombocytosis  Incomplete 
   - HAEM5:Myelodysplastic/myeloproliferative neoplasm, NOS  Incomplete 

Acute myeloid leukaemia
 Acute myeloid leukaemia with defining genetic abnormalities
   - HAEM5:Acute promyelocytic leukaemia with PML:RARA fusion  Incomplete 
   - HAEM5:Acute myeloid leukaemia with RUNX1:RUNX1T1 fusion  Complete 
   - HAEM5:Acute myeloid leukaemia with CBFB:MYH11 fusion  Complete 
   - HAEM5:Acute myeloid leukaemia with DEK:NUP214 fusion  Complete 
   - HAEM5:Acute myeloid leukaemia with RBM15:MRTFA fusion  Complete 
   - HAEM5:Acute myeloid leukaemia with BCR:ABL1 fusion  Complete 
   - HAEM5:Acute myeloid leukaemia with KMT2A rearrangement  Incomplete 
   - HAEM5:Acute myeloid leukaemia with MECOM rearrangement  Incomplete 
   - HAEM5:Acute myeloid leukaemia with NUP98 rearrangement  Incomplete 
   - HAEM5:Acute myeloid leukaemia with NPM1 mutation  Incomplete 
   - HAEM5:Acute myeloid leukaemia with CEBPA mutation  Incomplete 
   - HAEM5:Acute myeloid leukaemia, myelodysplasia-related  Incomplete 
   - HAEM5:Acute myeloid leukaemia with other defined genetic alterations  Incomplete 
 Acute myeloid leukaemia, defined by differentiation
   - HAEM5:Acute myeloid leukaemia with minimal differentiation  Incomplete 
   - HAEM5:Acute myeloid leukaemia without maturation  Incomplete 
   - HAEM5:Acute myeloid leukaemia with maturation  Incomplete 
   - HAEM5:Acute basophilic leukaemia  Incomplete 
   - HAEM5:Acute myelomonocytic leukaemia  Incomplete 
   - HAEM5:Acute monocytic leukaemia  Incomplete 
   - HAEM5:Acute erythroid leukaemia  Incomplete 
   - HAEM5:Acute megakaryoblastic leukaemia  Incomplete 
 Myeloid sarcoma
   - HAEM5:Myeloid sarcoma  Incomplete 

Myeloid neoplasms, secondary
 Myeloid neoplasms and proliferations associated with antecedent or predisposing conditions
   - HAEM5:Myeloid neoplasm post cytotoxic therapy  Incomplete 
   - HAEM5:Myeloid neoplasms associated with germline predisposition  Incomplete 
   - HAEM5:Myeloid proliferations associated with Down syndrome  Incomplete 

Myeloid/lymphoid neoplasms
 Myeloid/lymphoid neoplasms with eosinophilia and defining gene rearrangement
   - HAEM5:Myeloid/lymphoid neoplasm with PDGFRA rearrangement  Incomplete 
   - HAEM5:Myeloid/lymphoid neoplasm with PDGFRB rearrangement  Incomplete 
   - HAEM5:Myeloid/lymphoid neoplasm with FGFR1 rearrangement  Incomplete 
   - HAEM5:Myeloid/lymphoid neoplasm with JAK2 rearrangement  Incomplete 
   - HAEM5:Myeloid/lymphoid neoplasm with FLT3 rearrangement  Incomplete 
   - HAEM5:Myeloid/lymphoid neoplasm with ETV6:ABL1 fusion  Complete 
   - HAEM5:Myeloid/lymphoid neoplasms with other tyrosine kinase fusion genes  Incomplete 

Acute leukaemias of mixed or ambiguous lineage
 Acute leukaemia of ambiguous lineage with defining genetic abnormalities
   - HAEM5:Mixed-phenotype acute leukaemia with BCR:ABL1 fusion  Complete 
   - HAEM5:Mixed-phenotype acute leukaemia with KMT2A rearrangement  Incomplete 
   - HAEM5:Acute leukaemia of ambiguous lineage with other defined genetic alterations   Incomplete 
 Acute leukaemia of ambiguous lineage, immunophenotypically defined
   - HAEM5:Mixed-phenotype acute leukaemia, B/myeloid  Incomplete 
   - HAEM5:Mixed-phenotype acute leukaemia, T/myeloid  Incomplete 
   - HAEM5:Mixed-phenotype acute leukaemia, rare types  Incomplete 
   - HAEM5:Acute leukaemia of ambiguous lineage, NOS  Incomplete 
   - HAEM5:Acute undifferentiated leukaemia  Incomplete 

Histiocytic/Dendritic cell neoplasms

Plasmacytoid dendritic cell neoplasms
 Plasmacytoid dendritic cell neoplasms
   - HAEM5:Mature plasmacytoid dendritic cell proliferation associated with myeloid neoplasm  Incomplete 
   - HAEM5:Blastic plasmacytoid dendritic cell neoplasm  Incomplete 

Langerhans cell and other dendritic cell neoplasms
 Langerhans cells neoplasms
   - HAEM5:Langerhans cell histiocytosis  Incomplete 
   - HAEM5:Langerhans cell sarcoma  Incomplete 
 Other dendritic cell neoplasms
   - HAEM5:Indeterminate dendritic cell tumour  Incomplete 
   - HAEM5:Interdigitating dendritic cell sarcoma  Incomplete 

Histiocyte/macrophage neoplasms
 Histiocytic neoplasms
   - HAEM5:Juvenile xanthogranuloma  Complete 
   - HAEM5:Erdheim-Chester disease  Incomplete 
   - HAEM5:Rosai-Dorfman Disease  Incomplete 
   - HAEM5:ALK-positive histiocytosis  Incomplete 
   - HAEM5:Histiocytic sarcoma  Incomplete 

B-cell lymphoid proliferations and lymphomas

Tumour like lesions with B-cell predominance
   - HAEM5:Reactive B-cell rich lymphoid proliferations that can mimic lymphoma  Incomplete 
   - HAEM5:IgG4-related disease  Incomplete 
   - HAEM5:Unicentric Castleman disease  Incomplete 
   - HAEM5:Idiopathic multicentric Castleman disease  Incomplete 
   - HAEM5:KSHV/HHV8-associated multicentric Castleman disease  Incomplete 

Precursor B-cell neoplasms
 B-lymphoblastic leukaemias/lymphomas
   - HAEM5:B-lymphoblastic leukaemia/lymphoma  Incomplete 
   - HAEM5:B-lymphoblastic leukaemia/lymphoma with high hyperdiploidy  Incomplete 
   - HAEM5:B-lymphoblastic leukaemia/lymphoma with hypodiploidy  Incomplete 
   - HAEM5:B-lymphoblastic leukaemia/lymphoma with iAMP21  Complete 
   - HAEM5:B-lymphoblastic leukaemia/lymphoma with BCR:ABL1 fusion  Complete 
   - HAEM5:B-lymphoblastic leukaemia/lymphoma with BCR:ABL1-like features  Complete 
   - HAEM5:B lymphoblastic leukaemia/lymphoma with KMT2A rearrangement  Incomplete 
   - HAEM5:B lymphoblastic leukaemia/lymphoma with ETV6:RUNX1 fusion  Complete 
   - HAEM5:B-lymphoblastic leukaemia/lymphoma with ETV6:RUNX1-like features  Complete 
   - HAEM5:B lymphoblastic leukaemia/lymphoma with TCF3:PBX1 fusion  Complete 
   - HAEM5:B lymphoblastic leukaemia/lymphoma with IGH:IL3 fusion   Complete 
   - HAEM5:B lymphoblastic leukaemia/lymphoma with TCF3:HLF fusion  Complete 
   - HAEM5:B-lymphoblastic leukaemia/lymphoma with other defined genetic alterations  Incomplete 
   - HAEM5:B-lymphoblastic leukaemia/lymphoma, NOS  Incomplete 

Mature B-cell neoplasms
 Pre-neoplastic and neoplastic small lymphocytic proliferations 
   - HAEM5:Monoclonal B-cell lymphocytosis  Incomplete 
   - HAEM5:Chronic lymphocytic leukaemia/small lymphocytic lymphoma  Complete 
 Splenic B-cell lymphomas and leukaemias
   - HAEM5:Hairy cell leukaemia  Incomplete 
   - HAEM5:Splenic marginal zone lymphoma  Incomplete 
   - HAEM5:Splenic diffuse red pulp small B-cell lymphoma  Incomplete 
   - HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli  Incomplete 
 Lymphoplasmacytic lymphoma
   - HAEM5:Lymphoplasmacytic lymphoma  Incomplete 
 Marginal zone lymphoma
   - HAEM5:Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue  Incomplete 
   - HAEM5:Primary cutaneous marginal zone lymphoma   Incomplete 
   - HAEM5:Nodal marginal zone lymphoma  Incomplete 
   - HAEM5:Paediatric nodal marginal zone lymphoma  Incomplete 
 Follicular lymphoma
   - HAEM5:In situ follicular B-cell neoplasm  Incomplete 
   - HAEM5:Follicular lymphoma  Incomplete 
   - HAEM5:Paediatric-type follicular lymphoma  Incomplete 
   - HAEM5:Duodenal-type follicular lymphoma  Incomplete 
 Cutaneous follicle centre lymphoma
   - HAEM5:Primary cutaneous follicle centre lymphoma  Incomplete 
 Mantle cell lymphoma
   - HAEM5:In situ mantle cell neoplasm  Incomplete 
   - HAEM5:Mantle cell lymphoma  Incomplete 
   - HAEM5:Leukaemic non-nodal mantle cell lymphoma  Incomplete 
 Transformations of indolent B-cell lymphomas
   - HAEM5:Transformations of indolent B-cell lymphomas  Incomplete 
 Large B-cell lymphomas
   - HAEM5:Diffuse large B-cell lymphoma, NOS  Incomplete 
   - HAEM5:T-cell/histiocyte-rich large B-cell lymphoma  Incomplete 
   - HAEM5:Diffuse large B-cell lymphoma / high grade B-cell lymphoma with MYC and BCL2 rearrangements  Incomplete 
   - HAEM5:ALK-positive large B-cell lymphoma  Incomplete 
   - HAEM5:Large B-cell lymphoma with IRF4 rearrangement  Incomplete 
   - HAEM5:High grade B-cell lymphoma with 11q aberrations  Incomplete 
   - HAEM5:Lymphomatoid granulomatosis  Incomplete 
   - HAEM5:EBV-positive diffuse large B-cell lymphoma  Incomplete 
   - HAEM5:Diffuse large B-cell lymphoma associated with chronic inflammation  Incomplete 
   - HAEM5:Fibrin-associated large B-cell lymphoma  Incomplete 
   - HAEM5:Fluid overload-associated large B-cell lymphoma  Incomplete 
   - HAEM5:Plasmablastic lymphoma  Incomplete 
   - HAEM5:Primary large B-cell lymphoma of immune-privileged sites  Incomplete 
   - HAEM5:Primary cutaneous diffuse large B-cell lymphoma, leg type  Incomplete 
   - HAEM5:Intravascular large B-cell lymphoma  Incomplete 
   - HAEM5:Primary mediastinal large B-cell lymphoma  Incomplete 
   - HAEM5:Mediastinal grey zone lymphoma  Incomplete 
   - HAEM5:High-grade B-cell lymphoma, NOS  Incomplete 
 Burkitt lymphoma
   - HAEM5:Burkitt lymphoma  Incomplete 
 KSHV/HHV8-associated B-cell lymphoid proliferations and lymphomas
   - HAEM5:Primary effusion lymphoma  Incomplete 
   - HAEM5:KSHV/HHV8-positive diffuse large B-cell lymphoma  Incomplete 
   - HAEM5:KSHV/HHV8-positive germinotropic lymphoproliferative disorder  Incomplete 
 Lymphoid proliferations and lymphomas associated with immune deficiency and dysregulation
   - HAEM5:Hyperplasias arising in immune deficiency/dysregulation  Incomplete 
   - HAEM5:Polymorphic lymphoproliferative disorders arising in immune deficiency / dysregulation   Incomplete 
   - HAEM5:EBV-positive mucocutaneous ulcer  Incomplete 
   - HAEM5:Lymphomas arising in immune deficiency / dysregulation   Incomplete 
   - HAEM5:Inborn error of immunity-associated lymphoid proliferations and lymphomas  Incomplete 

Hodgkin lymphoma
   - HAEM5:Classic Hodgkin lymphoma   Incomplete 
   - HAEM5:Nodular lymphocyte predominant Hodgkin lymphoma  Incomplete 

Plasma cell neoplasms and other diseases with paraproteins
 Monoclonal gammopathies
   - HAEM5:Cold agglutinin disease   Incomplete 
   - HAEM5:IgM monoclonal gammopathy of undetermined significance  Incomplete 
   - HAEM5:Non-IgM monoclonal gammopathy of undetermined significance  Incomplete 
   - HAEM5:Monoclonal gammopathy of renal significance  Incomplete 
 Diseases with monoclonal immunoglobulin deposition
   - HAEM5:Immunoglobulin-related (AL) amyloidosis  Incomplete 
   - HAEM5:Monoclonal immunoglobulin deposition disease  Incomplete 
 Heavy chain diseases
   - HAEM5:Mu heavy chain disease  Incomplete 
   - HAEM5:Gamma heavy chain disease  Incomplete 
   - HAEM5:Alpha heavy chain disease  Incomplete 
 Plasma cell neoplasms
   - HAEM5:Plasmacytoma  Incomplete 
   - HAEM5:Plasma cell myeloma / multiple myeloma  Incomplete 
   - HAEM5:Plasma cell neoplasms with associated paraneoplastic syndrome  Incomplete 

T-cell and NK-cell lymphoid proliferations and lymphomas

Tumour-like lesions with T-cell predominance
   - HAEM5:Kikuchi-Fujimoto disease  Complete 
   - HAEM5:Autoimmune lymphoproliferative syndrome  Incomplete 
   - HAEM5:Indolent T-lymphoblastic proliferation  Incomplete 

Precursor T-cell neoplasms
 T-lymphoblastic leukaemia / lymphoma
   - HAEM5:T-lymphoblastic leukaemia / lymphoma, NOS  Incomplete 
   - HAEM5:Early T-precursor lymphoblastic leukaemia / lymphoma   Incomplete 

Mature T-cell and NK-cell neoplasms
 Mature T-cell and NK-cell leukaemias
   - HAEM5:T-prolymphocytic leukaemia  Complete 
   - HAEM5:T-large granular lymphocytic leukaemia  Incomplete 
   - HAEM5:NK-large granular lymphocytic leukaemia  Complete 
   - HAEM5:Adult T-cell leukaemia/lymphoma  Incomplete 
   - HAEM5:Sezary syndrome  Incomplete 
   - HAEM5:Aggressive NK-cell leukaemia  Incomplete 
 Primary cutaneous T-cell lymphoid proliferations and lymphomas
   - HAEM5:Primary cutaneous CD4-positive small or medium T-cell lymphoproliferative disorder  Incomplete 
   - HAEM5:Primary cutaneous acral CD8-positive T-cell lymphoproliferative disorder  Complete 
   - HAEM5:Mycosis fungoides  Incomplete 
   - HAEM5:Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Lymphomatoid papulosis  Incomplete 
   - HAEM5:Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Primary cutaneous anaplastic large cell lymphoma  Incomplete 
   - HAEM5:Subcutaneous panniculitis-like T-cell lymphoma  Complete 
   - HAEM5:Primary cutaneous gamma/delta T-cell lymphoma  Complete 
   - HAEM5:Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma  Complete 
   - HAEM5:Primary cutaneous peripheral T-cell lymphoma, NOS  Incomplete 
 Intestinal T-cell and NK-cell lymphoid proliferations and lymphomas
   - HAEM5:Indolent T-cell lymphoma of the gastrointestinal tract  Incomplete 
   - HAEM5:Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract  Incomplete 
   - HAEM5:Enteropathy-associated T-cell lymphoma  Incomplete 
   - HAEM5:Monomorphic epitheliotropic intestinal T-cell lymphoma  Incomplete 
   - HAEM5:Intestinal T-cell lymphoma, NOS  Incomplete 
 Hepatosplenic T-cell lymphoma
   - HAEM5:Hepatosplenic T-cell lymphoma  Complete 
 Anaplastic large cell lymphoma
   - HAEM5:ALK-positive anaplastic large cell lymphoma  Incomplete 
   - HAEM5:ALK-negative anaplastic large cell lymphoma  Incomplete 
   - HAEM5:Breast implant-associated anaplastic large cell lymphoma  Incomplete 
 Nodal T-follicular helper (TFH) cell lymphoma
   - HAEM5:Nodal TFH cell lymphoma, angioimmunoblastic-type  Incomplete 
   - HAEM5:Nodal TFH cell lymphoma, follicular-type  Incomplete 
   - HAEM5:Nodal TFH cell lymphoma, NOS  Incomplete 
 Other peripheral T-cell lymphomas
   - HAEM5:Peripheral T-cell lymphoma, NOS  Incomplete 
 EBV-positive NK-cell and T-cell lymphomas
   - HAEM5:EBV-positive nodal T- and NK-cell lymphoma  Incomplete 
   - HAEM5:Extranodal NK/T-cell lymphoma  Complete 
 EBV-positive T-cell and NK-cell lymphoid proliferations and lymphomas of childhood
   - HAEM5:Severe mosquito bite allergy  Incomplete 
   - HAEM5:Hydroa vacciniforme lymphoproliferative disorder  Incomplete 
   - HAEM5:Systemic chronic active EBV disease  Complete 
   - HAEM5:Systemic EBV-positive T-cell lymphoma of childhood  Complete 

Stroma-derived neoplasms of lymphoid tissues

Mesenchymal dendritic cell neoplasms
 Follicular dendritic cell neoplasms
   - HAEM5:Follicular dendritic cell sarcoma  Incomplete 
   - HAEM5:EBV-positive inflammatory follicular dendritic cell sarcoma  Incomplete 
   - HAEM5:Fibroblastic reticular cell tumour  Incomplete 

Myofibroblastic tumours
 Myofibroblastic tumour
   - HAEM5:Intranodal palisaded myofibroblastoma  Incomplete 

Spleen-specific vascular-stromal tumours
 Splenic vascular-stromal tumours
   - HAEM5:Littoral cell angioma  Incomplete 
   - HAEM5:Splenic hamartoma  Incomplete 
   - HAEM5:Sclerosing angiomatoid nodular transformation (SANT) of spleen  Incomplete 

Genetic tumour syndromes

   - HAEM5:Fanconi anaemia  Incomplete 
   - GTS5:Bloom syndrome (BLM)  Incomplete 
   - HAEM5:Ataxia-telangiectasia syndrome  Incomplete 
   - HAEM5:RASopathies  Incomplete