Haematolymphoid Tumours 5th ed. (HAEM5) Table of Contents

Myeloid proliferations and neoplasms

Myeloid precursor lesions
 Clonal Haematopoiesis
   - HAEM5:Clonal haematopoiesis 
   - HAEM5:Clonal cytopenias of undetermined significance 

Myeloproliferative neoplasms
 Myeloproliferative neoplasms
   - HAEM5:Chronic myeloid leukaemia 
   - HAEM5:Chronic neutrophilic leukaemia 
   - HAEM5:Chronic eosinophilic leukaemia  Complete 
   - HAEM5:Polycythaemia vera 
   - HAEM5:Essential thrombocythaemia 
   - HAEM5:Primary myelofibrosis 
   - HAEM5:Juvenile myelomonocytic leukaemia 
   - HAEM5:Myeloproliferative neoplasm, NOS 

Mastocytosis
   - HAEM5:Cutaneous mastocytosis 
   - HAEM5:Systemic mastocytosis 
   - HAEM5:Mast cell sarcoma 

Myelodysplastic neoplasms
 Myelodysplastic neoplasms, with defining genetic abnormalities
   - HAEM5:Myelodysplastic neoplasm with low blasts and 5q deletion 
   - HAEM5:Myelodysplastic neoplasm with low blasts and SF3B1 mutation 
   - HAEM5:Myelodysplastic neoplasm with biallelic TP53 inactivation  Complete 
 Myelodysplastic neoplasms, morphologically defined
   - HAEM5:Myelodysplastic neoplasm with low blasts 
   - HAEM5:Myelodysplastic neoplasm, hypoplastic 
   - HAEM5:Myelodysplastic neoplasm with increased blasts 
 Myelodysplastic neoplasms of childhood
   - HAEM5:Childhood myelodysplastic neoplasm with low blasts 
   - HAEM5:Childhood myelodysplastic neoplasm with increased blasts 

Myelodysplastic/myeloproliferative neoplasms
   - HAEM5:Chronic myelomonocytic leukaemia 
   - HAEM5:Myelodysplastic/myeloproliferative neoplasm with neutrophilia 
   - HAEM5:Myelodysplastic/myeloproliferative neoplasm with SF3B1 mutation and thrombocytosis 
   - HAEM5:Myelodysplastic/myeloproliferative neoplasm, NOS 

Acute myeloid leukaemia
 Acute myeloid leukaemia with defining genetic abnormalities
   - HAEM5:Acute promyelocytic leukaemia with PML:RARA fusion 
   - HAEM5:Acute myeloid leukaemia with RUNX1:RUNX1T1 fusion  Complete 
   - HAEM5:Acute myeloid leukaemia with CBFB:MYH11 fusion  Complete 
   - HAEM5:Acute myeloid leukaemia with DEK:NUP214 fusion  Complete 
   - HAEM5:Acute myeloid leukaemia with RBM15:MRTFA fusion  Complete 
   - HAEM5:Acute myeloid leukaemia with BCR:ABL1 fusion  Complete 
   - HAEM5:Acute myeloid leukaemia with KMT2A rearrangement 
   - HAEM5:Acute myeloid leukaemia with MECOM rearrangement 
   - HAEM5:Acute myeloid leukaemia with NUP98 rearrangement 
   - HAEM5:Acute myeloid leukaemia with NPM1 mutation 
   - HAEM5:Acute myeloid leukaemia with CEBPA mutation 
   - HAEM5:Acute myeloid leukaemia, myelodysplasia-related 
   - HAEM5:Acute myeloid leukaemia with other defined genetic alterations 
 Acute myeloid leukaemia, defined by differentiation
   - HAEM5:Acute myeloid leukaemia with minimal differentiation 
   - HAEM5:Acute myeloid leukaemia without maturation 
   - HAEM5:Acute myeloid leukaemia with maturation 
   - HAEM5:Acute basophilic leukaemia 
   - HAEM5:Acute myelomonocytic leukaemia 
   - HAEM5:Acute monocytic leukaemia 
   - HAEM5:Acute erythroid leukaemia 
   - HAEM5:Acute megakaryoblastic leukaemia 
 Myeloid sarcoma
   - HAEM5:Myeloid sarcoma 

Myeloid neoplasms, secondary
 Myeloid neoplasms and proliferations associated with antecedent or predisposing conditions
   - HAEM5:Myeloid neoplasm post cytotoxic therapy 
   - HAEM5:Myeloid neoplasms associated with germline predisposition 
   - HAEM5:Myeloid proliferations associated with Down syndrome 

Myeloid/lymphoid neoplasms
 Myeloid/lymphoid neoplasms with eosinophilia and defining gene rearrangement
   - HAEM5:Myeloid/lymphoid neoplasm with PDGFRA rearrangement 
   - HAEM5:Myeloid/lymphoid neoplasm with PDGFRB rearrangement 
   - HAEM5:Myeloid/lymphoid neoplasm with FGFR1 rearrangement 
   - HAEM5:Myeloid/lymphoid neoplasm with JAK2 rearrangement 
   - HAEM5:Myeloid/lymphoid neoplasm with FLT3 rearrangement 
   - HAEM5:Myeloid/lymphoid neoplasm with ETV6:ABL1 fusion  Complete 
   - HAEM5:Myeloid/lymphoid neoplasms with other tyrosine kinase fusion genes 

Acute leukaemias of mixed or ambiguous lineage
 Acute leukaemia of ambiguous lineage with defining genetic abnormalities
   - HAEM5:Mixed-phenotype acute leukaemia with BCR:ABL1 fusion  Complete 
   - HAEM5:Mixed-phenotype acute leukaemia with KMT2A rearrangement 
   - HAEM5:Acute leukaemia of ambiguous lineage with other defined genetic alterations  
 Acute leukaemia of ambiguous lineage, immunophenotypically defined
   - HAEM5:Mixed-phenotype acute leukaemia, B/myeloid 
   - HAEM5:Mixed-phenotype acute leukaemia, T/myeloid 
   - HAEM5:Mixed-phenotype acute leukaemia, rare types 
   - HAEM5:Acute leukaemia of ambiguous lineage, NOS 
   - HAEM5:Acute undifferentiated leukaemia 

Histiocytic/Dendritic cell neoplasms

Plasmacytoid dendritic cell neoplasms
 Plasmacytoid dendritic cell neoplasms
   - HAEM5:Mature plasmacytoid dendritic cell proliferation associated with myeloid neoplasm 
   - HAEM5:Blastic plasmacytoid dendritic cell neoplasm 

Langerhans cell and other dendritic cell neoplasms
 Langerhans cells neoplasms
   - HAEM5:Langerhans cell histiocytosis 
   - HAEM5:Langerhans cell sarcoma 
 Other dendritic cell neoplasms
   - HAEM5:Indeterminate dendritic cell tumour 
   - HAEM5:Interdigitating dendritic cell sarcoma 

Histiocyte/macrophage neoplasms
 Histiocytic neoplasms
   - HAEM5:Juvenile xanthogranuloma  Complete 
   - HAEM5:Erdheim-Chester disease 
   - HAEM5:Rosai-Dorfman Disease 
   - HAEM5:ALK-positive histiocytosis 
   - HAEM5:Histiocytic sarcoma 

B-cell lymphoid proliferations and lymphomas

Tumour like lesions with B-cell predominance
   - HAEM5:Reactive B-cell rich lymphoid proliferations that can mimic lymphoma 
   - HAEM5:IgG4-related disease 
   - HAEM5:Unicentric Castleman disease 
   - HAEM5:Idiopathic multicentric Castleman disease 
   - HAEM5:KSHV/HHV8-associated multicentric Castleman disease 

Precursor B-cell neoplasms
 B-lymphoblastic leukaemias/lymphomas
   - HAEM5:B-lymphoblastic leukaemia/lymphoma 
   - HAEM5:B-lymphoblastic leukaemia/lymphoma with high hyperdiploidy 
   - HAEM5:B-lymphoblastic leukaemia/lymphoma with hypodiploidy 
   - HAEM5:B-lymphoblastic leukaemia/lymphoma with iAMP21  Complete 
   - HAEM5:B-lymphoblastic leukaemia/lymphoma with BCR:ABL1 fusion  Complete 
   - HAEM5:B-lymphoblastic leukaemia/lymphoma with BCR:ABL1-like features  Complete 
   - HAEM5:B lymphoblastic leukaemia/lymphoma with KMT2A rearrangement 
   - HAEM5:B lymphoblastic leukaemia/lymphoma with ETV6:RUNX1 fusion  Complete 
   - HAEM5:B-lymphoblastic leukaemia/lymphoma with ETV6:RUNX1-like features  Complete 
   - HAEM5:B lymphoblastic leukaemia/lymphoma with TCF3:PBX1 fusion  Complete 
   - HAEM5:B lymphoblastic leukaemia/lymphoma with IGH:IL3 fusion   Complete 
   - HAEM5:B lymphoblastic leukaemia/lymphoma with TCF3:HLF fusion  Complete 
   - HAEM5:B-lymphoblastic leukaemia/lymphoma with other defined genetic alterations 
   - HAEM5:B-lymphoblastic leukaemia/lymphoma, NOS 

Mature B-cell neoplasms
 Pre-neoplastic and neoplastic small lymphocytic proliferations 
   - HAEM5:Monoclonal B-cell lymphocytosis 
   - HAEM5:Chronic lymphocytic leukaemia/small lymphocytic lymphoma  Complete 
 Splenic B-cell lymphomas and leukaemias
   - HAEM5:Hairy cell leukaemia 
   - HAEM5:Splenic marginal zone lymphoma 
   - HAEM5:Splenic diffuse red pulp small B-cell lymphoma 
   - HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli 
 Lymphoplasmacytic lymphoma
   - HAEM5:Lymphoplasmacytic lymphoma 
 Marginal zone lymphoma
   - HAEM5:Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue 
   - HAEM5:Primary cutaneous marginal zone lymphoma  
   - HAEM5:Nodal marginal zone lymphoma 
   - HAEM5:Paediatric nodal marginal zone lymphoma 
 Follicular lymphoma
   - HAEM5:In situ follicular B-cell neoplasm 
   - HAEM5:Follicular lymphoma 
   - HAEM5:Paediatric-type follicular lymphoma 
   - HAEM5:Duodenal-type follicular lymphoma 
 Cutaneous follicle centre lymphoma
   - HAEM5:Primary cutaneous follicle centre lymphoma 
 Mantle cell lymphoma
   - HAEM5:In situ mantle cell neoplasm 
   - HAEM5:Mantle cell lymphoma 
   - HAEM5:Leukaemic non-nodal mantle cell lymphoma 
 Transformations of indolent B-cell lymphomas
   - HAEM5:Transformations of indolent B-cell lymphomas 
 Large B-cell lymphomas
   - HAEM5:Diffuse large B-cell lymphoma, NOS 
   - HAEM5:T-cell/histiocyte-rich large B-cell lymphoma 
   - HAEM5:Diffuse large B-cell lymphoma / high grade B-cell lymphoma with MYC and BCL2 rearrangements 
   - HAEM5:ALK-positive large B-cell lymphoma 
   - HAEM5:Large B-cell lymphoma with IRF4 rearrangement 
   - HAEM5:High grade B-cell lymphoma with 11q aberrations 
   - HAEM5:Lymphomatoid granulomatosis 
   - HAEM5:EBV-positive diffuse large B-cell lymphoma 
   - HAEM5:Diffuse large B-cell lymphoma associated with chronic inflammation 
   - HAEM5:Fibrin-associated large B-cell lymphoma 
   - HAEM5:Fluid overload-associated large B-cell lymphoma 
   - HAEM5:Plasmablastic lymphoma 
   - HAEM5:Primary large B-cell lymphoma of immune-privileged sites 
   - HAEM5:Primary cutaneous diffuse large B-cell lymphoma, leg type 
   - HAEM5:Intravascular large B-cell lymphoma 
   - HAEM5:Primary mediastinal large B-cell lymphoma 
   - HAEM5:Mediastinal grey zone lymphoma 
   - HAEM5:High-grade B-cell lymphoma, NOS 
 Burkitt lymphoma
   - HAEM5:Burkitt lymphoma 
 KSHV/HHV8-associated B-cell lymphoid proliferations and lymphomas
   - HAEM5:Primary effusion lymphoma 
   - HAEM5:KSHV/HHV8-positive diffuse large B-cell lymphoma 
   - HAEM5:KSHV/HHV8-positive germinotropic lymphoproliferative disorder 
 Lymphoid proliferations and lymphomas associated with immune deficiency and dysregulation
   - HAEM5:Hyperplasias arising in immune deficiency/dysregulation 
   - HAEM5:Polymorphic lymphoproliferative disorders arising in immune deficiency / dysregulation  
   - HAEM5:EBV-positive mucocutaneous ulcer 
   - HAEM5:Lymphomas arising in immune deficiency / dysregulation  
   - HAEM5:Inborn error of immunity-associated lymphoid proliferations and lymphomas 

Hodgkin lymphoma
   - HAEM5:Classic Hodgkin lymphoma  
   - HAEM5:Nodular lymphocyte predominant Hodgkin lymphoma 

Plasma cell neoplasms and other diseases with paraproteins
 Monoclonal gammopathies
   - HAEM5:Cold agglutinin disease  
   - HAEM5:IgM monoclonal gammopathy of undetermined significance 
   - HAEM5:Non-IgM monoclonal gammopathy of undetermined significance 
   - HAEM5:Monoclonal gammopathy of renal significance 
 Diseases with monoclonal immunoglobulin deposition
   - HAEM5:Immunoglobulin-related (AL) amyloidosis 
   - HAEM5:Monoclonal immunoglobulin deposition disease 
 Heavy chain diseases
   - HAEM5:Mu heavy chain disease 
   - HAEM5:Gamma heavy chain disease 
   - HAEM5:Alpha heavy chain disease 
 Plasma cell neoplasms
   - HAEM5:Plasmacytoma 
   - HAEM5:Plasma cell myeloma / multiple myeloma 
   - HAEM5:Plasma cell neoplasms with associated paraneoplastic syndrome 

T-cell and NK-cell lymphoid proliferations and lymphomas

Tumour-like lesions with T-cell predominance
   - HAEM5:Kikuchi-Fujimoto disease  Complete 
   - HAEM5:Autoimmune lymphoproliferative syndrome 
   - HAEM5:Indolent T-lymphoblastic proliferation 

Precursor T-cell neoplasms
 T-lymphoblastic leukaemia / lymphoma
   - HAEM5:T-lymphoblastic leukaemia / lymphoma, NOS 
   - HAEM5:Early T-precursor lymphoblastic leukaemia / lymphoma  

Mature T-cell and NK-cell neoplasms
 Mature T-cell and NK-cell leukaemias
   - HAEM5:T-prolymphocytic leukaemia  Complete 
   - HAEM5:T-large granular lymphocytic leukaemia 
   - HAEM5:NK-large granular lymphocytic leukaemia  Complete 
   - HAEM5:Adult T-cell leukaemia/lymphoma 
   - HAEM5:Sezary syndrome 
   - HAEM5:Aggressive NK-cell leukaemia 
 Primary cutaneous T-cell lymphoid proliferations and lymphomas
   - HAEM5:Primary cutaneous CD4-positive small or medium T-cell lymphoproliferative disorder 
   - HAEM5:Primary cutaneous acral CD8-positive T-cell lymphoproliferative disorder  Complete 
   - HAEM5:Mycosis fungoides 
   - HAEM5:Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Lymphomatoid papulosis 
   - HAEM5:Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Primary cutaneous anaplastic large cell lymphoma 
   - HAEM5:Subcutaneous panniculitis-like T-cell lymphoma  Complete 
   - HAEM5:Primary cutaneous gamma/delta T-cell lymphoma  Complete 
   - HAEM5:Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma  Complete 
   - HAEM5:Primary cutaneous peripheral T-cell lymphoma, NOS 
 Intestinal T-cell and NK-cell lymphoid proliferations and lymphomas
   - HAEM5:Indolent T-cell lymphoma of the gastrointestinal tract 
   - HAEM5:Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract 
   - HAEM5:Enteropathy-associated T-cell lymphoma 
   - HAEM5:Monomorphic epitheliotropic intestinal T-cell lymphoma 
   - HAEM5:Intestinal T-cell lymphoma, NOS 
 Hepatosplenic T-cell lymphoma
   - HAEM5:Hepatosplenic T-cell lymphoma  Complete 
 Anaplastic large cell lymphoma
   - HAEM5:ALK-positive anaplastic large cell lymphoma 
   - HAEM5:ALK-negative anaplastic large cell lymphoma 
   - HAEM5:Breast implant-associated anaplastic large cell lymphoma 
 Nodal T-follicular helper (TFH) cell lymphoma
   - HAEM5:Nodal TFH cell lymphoma, angioimmunoblastic-type 
   - HAEM5:Nodal TFH cell lymphoma, follicular-type 
   - HAEM5:Nodal TFH cell lymphoma, NOS 
 Other peripheral T-cell lymphomas
   - HAEM5:Peripheral T-cell lymphoma, NOS 
 EBV-positive NK-cell and T-cell lymphomas
   - HAEM5:EBV-positive nodal T- and NK-cell lymphoma 
   - HAEM5:Extranodal NK/T-cell lymphoma  Complete 
 EBV-positive T-cell and NK-cell lymphoid proliferations and lymphomas of childhood
   - HAEM5:Severe mosquito bite allergy 
   - HAEM5:Hydroa vacciniforme lymphoproliferative disorder 
   - HAEM5:Systemic chronic active EBV disease  Complete 
   - HAEM5:Systemic EBV-positive T-cell lymphoma of childhood  Complete 

Stroma-derived neoplasms of lymphoid tissues

Mesenchymal dendritic cell neoplasms
 Follicular dendritic cell neoplasms
   - HAEM5:Follicular dendritic cell sarcoma 
   - HAEM5:EBV-positive inflammatory follicular dendritic cell sarcoma 
   - HAEM5:Fibroblastic reticular cell tumour 

Myofibroblastic tumours
 Myofibroblastic tumour
   - HAEM5:Intranodal palisaded myofibroblastoma 

Spleen-specific vascular-stromal tumours
 Splenic vascular-stromal tumours
   - HAEM5:Littoral cell angioma 
   - HAEM5:Splenic hamartoma 
   - HAEM5:Sclerosing angiomatoid nodular transformation (SANT) of spleen 

Genetic tumour syndromes

   - HAEM5:Fanconi anaemia 
   - GTS5:Bloom syndrome (BLM) 
   - HAEM5:Ataxia-telangiectasia syndrome 
   - HAEM5:RASopathies