From Compendium of Cancer Genome Aberrations
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| Alteration
|
Relevant Gene(s)
|
CGC Evidence Level
|
Subgroup Association(s)
|
| 1q gain
|
unknown
|
2
|
Most common copy number alteration, often with 16q loss; all subtypes
|
| 8p11.2 amplification
|
FGFR1, ZNF703
|
2
|
METABRIC IntClust6, ER positive
|
| 8q24 amplification
|
MYC
|
2
|
METABRIC IntClust9, ER positive
|
| 9p24 amplification
|
JAK2, CD274, PDCD1LG2
|
2
|
Enriched in TNBC
|
| 10q23.3 loss or LOH
|
PTEN
|
2
|
Enriched in TNBC and in lobular carcinoma
|
| 11q13-q14 gain / amplification
|
CCND1, EMS1, and others
|
2
|
METABRIC IntClust2
|
| 16q loss / LOH
|
CDH1
|
2
|
METABRIC IntClust2, ER positive
|
| 17p loss / LOH
|
TP53
|
2
|
TNBC, basal-like intrinsic subtype
|
| 17q12 amplification
|
ERBB2 (HER2)
|
1
|
METABRIC IntClust5, HER2-enriched
|
| 17q21 amplification
|
TOP2A
|
2
|
METABRIC IntClust5, HER2-enriched
|
| 17q23 amplification (“17q distal amplicon”)
|
RPS6KB, others
|
2
|
METABRIC IntClust1
|
| 19q12
|
CCNE1
|
2
|
METABRIC IntClust5; HER2-enriched
|
| 20q gain; 20q13 amp
|
AURKA, GNAS, ZNF217
|
2
|
METABRIC IntClust1, ER Positive
|