Haematolymphoid Tumours 5th ed. (HAEM5) Table of Contents

Myeloid proliferations and neoplasms

Myeloid precursor lesions
 Clonal Haematopoiesis
   - HAEM5:Clonal haematopoiesis Page Status: Incomplete
   - HAEM5:Clonal cytopenias of undetermined significance Page Status: Incomplete

Myeloproliferative neoplasms
 Myeloproliferative neoplasms
   - HAEM5:Chronic myeloid leukaemia Page Status: Incomplete 
   - HAEM5:Chronic neutrophilic leukaemia Page Status: Incomplete
   - HAEM5:Chronic eosinophilic leukaemia Page Status: Complete
   - HAEM5:Polycythaemia vera Page Status: Incomplete
   - HAEM5:Essential thrombocythaemia Page Status: Incomplete
   - HAEM5:Primary myelofibrosis Page Status: Incomplete
   - HAEM5:Juvenile myelomonocytic leukaemia Page Status: Incomplete
   - HAEM5:Myeloproliferative neoplasm, NOS Page Status: Incomplete 

Mastocytosis
   - HAEM5:Cutaneous mastocytosis Page Status: Incomplete
   - HAEM5:Systemic mastocytosis Page Status: Incomplete
   - HAEM5:Mast cell sarcoma Page Status: Incomplete

Myelodysplastic neoplasms
 Myelodysplastic neoplasms, with defining genetic abnormalities
   - HAEM5:Myelodysplastic neoplasm with low blasts and 5q deletion Page Status: Incomplete
   - HAEM5:Myelodysplastic neoplasm with low blasts and SF3B1 mutation Page Status: Incomplete
   - HAEM5:Myelodysplastic neoplasm with biallelic TP53 inactivation Page Status: Complete
 Myelodysplastic neoplasms, morphologically defined
   - HAEM5:Myelodysplastic neoplasm with low blasts Page Status: Incomplete
   - HAEM5:Myelodysplastic neoplasm, hypoplastic Page Status: Incomplete
   - HAEM5:Myelodysplastic neoplasm with increased blasts Page Status: Incomplete
 Myelodysplastic neoplasms of childhood
   - HAEM5:Childhood myelodysplastic neoplasm with low blasts Page Status: Incomplete
   - HAEM5:Childhood myelodysplastic neoplasm with increased blasts Page Status: Incomplete

Myelodysplastic/myeloproliferative neoplasms
   - HAEM5:Chronic myelomonocytic leukaemia Page Status: Incomplete
   - HAEM5:Myelodysplastic/myeloproliferative neoplasm with neutrophilia Page Status: Incomplete
   - HAEM5:Myelodysplastic/myeloproliferative neoplasm with SF3B1 mutation and thrombocytosis Page Status: Incomplete
   - HAEM5:Myelodysplastic/myeloproliferative neoplasm, NOS Page Status: Incomplete

Acute myeloid leukaemia
 Acute myeloid leukaemia with defining genetic abnormalities
   - RARA fusion Page Status: Incomplete
   - RUNX1T1 fusion Page Status: Incomplete
   - MYH11 fusion Page Status: Incomplete
   - NUP214 fusion Page Status: Complete
   - MRTFA fusion Page Status: Complete
   - ABL1 fusion Page Status: Incomplete
   - HAEM5:Acute myeloid leukaemia with KMT2A rearrangement Page Status: Incomplete
   - HAEM5:Acute myeloid leukaemia with MECOM rearrangement Page Status: Incomplete
   - HAEM5:Acute myeloid leukaemia with NUP98 rearrangement Page Status: Incomplete
   - HAEM5:Acute myeloid leukaemia with NPM1 mutation Page Status: Incomplete
   - HAEM5:Acute myeloid leukaemia with CEBPA mutation Page Status: Incomplete
   - HAEM5:Acute myeloid leukaemia, myelodysplasia-related Page Status: Incomplete
   - HAEM5:Acute myeloid leukaemia with other defined genetic alterations Page Status: Incomplete
 Acute myeloid leukaemia, defined by differentiation
   - HAEM5:Acute myeloid leukaemia with minimal differentiation Page Status: Incomplete
   - HAEM5:Acute myeloid leukaemia without maturation Page Status: Incomplete
   - HAEM5:Acute myeloid leukaemia with maturation Page Status: Incomplete
   - HAEM5:Acute basophilic leukaemia Page Status: Incomplete
   - HAEM5:Acute myelomonocytic leukaemia Page Status: Incomplete
   - HAEM5:Acute monocytic leukaemia Page Status: Incomplete
   - HAEM5:Acute erythroid leukaemia Page Status: Incomplete
   - HAEM5:Acute megakaryoblastic leukaemia Page Status: Incomplete
 Myeloid sarcoma
   - HAEM5:Myeloid sarcoma Page Status: Incomplete

Myeloid neoplasms, secondary
 Myeloid neoplasms and proliferations associated with antecedent or predisposing conditions
   - HAEM5:Myeloid neoplasm post cytotoxic therapy Page Status: Incomplete
   - HAEM5:Myeloid neoplasms associated with germline predisposition Page Status: Incomplete
   - HAEM5:Myeloid proliferations associated with Down syndrome Page Status: Incomplete

Myeloid/lymphoid neoplasms
 Myeloid/lymphoid neoplasms with eosinophilia and defining gene rearrangement
   - HAEM5:Myeloid/lymphoid neoplasm with PDGFRA rearrangement Page Status: Incomplete
   - HAEM5:Myeloid/lymphoid neoplasm with PDGFRB rearrangement Page Status: Incomplete
   - HAEM5:Myeloid/lymphoid neoplasm with FGFR1 rearrangement Page Status: Incomplete
   - HAEM5:Myeloid/lymphoid neoplasm with JAK2 rearrangement Page Status: Incomplete
   - HAEM5:Myeloid/lymphoid neoplasm with FLT3 rearrangement Page Status: Incomplete
   - ABL1 fusion Page Status: Incomplete
   - HAEM5:Myeloid/lymphoid neoplasms with other tyrosine kinase fusion genes Page Status: Incomplete

Acute leukaemias of mixed or ambiguous lineage
 Acute leukaemia of ambiguous lineage with defining genetic abnormalities
   - ABL1 fusion Page Status: Incomplete
   - HAEM5:Mixed-phenotype acute leukaemia with KMT2A rearrangement Page Status: Incomplete
   - HAEM5:Acute leukaemia of ambiguous lineage with other defined genetic alterations  Page Status: Incomplete
 Acute leukaemia of ambiguous lineage, immunophenotypically defined
   - HAEM5:Mixed-phenotype acute leukaemia, B/myeloid Page Status: Incomplete
   - HAEM5:Mixed-phenotype acute leukaemia, T/myeloid Page Status: Incomplete
   - HAEM5:Mixed-phenotype acute leukaemia, rare types Page Status: Incomplete
   - HAEM5:Acute leukaemia of ambiguous lineage, NOS Page Status: Incomplete
   - HAEM5:Acute undifferentiated leukaemia Page Status: Incomplete

Histiocytic/Dendritic cell neoplasms

Plasmacytoid dendritic cell neoplasms
 Plasmacytoid dendritic cell neoplasms
   - HAEM5:Mature plasmacytoid dendritic cell proliferation associated with myeloid neoplasm Page Status: Incomplete
   - HAEM5:Blastic plasmacytoid dendritic cell neoplasm Page Status: Incomplete

Langerhans cell and other dendritic cell neoplasms
 Langerhans cells neoplasms
   - HAEM5:Langerhans cell histiocytosis Page Status: Incomplete
   - HAEM5:Langerhans cell sarcoma Page Status: Incomplete
 Other dendritic cell neoplasms
   - HAEM5:Indeterminate dendritic cell tumour Page Status: Incomplete
   - HAEM5:Interdigitating dendritic cell sarcoma Page Status: Incomplete

Histiocyte/macrophage neoplasms
 Histiocytic neoplasms
   - HAEM5:Juvenile xanthogranuloma Page Status: Complete
   - HAEM5:Erdheim-Chester disease Page Status: Incomplete
   - HAEM5:Rosai-Dorfman Disease Page Status: Incomplete
   - HAEM5:ALK-positive histiocytosis Page Status: Incomplete
   - HAEM5:Histiocytic sarcoma Page Status: Incomplete

B-cell lymphoid proliferations and lymphomas

Tumour like lesions with B-cell predominance
   - HAEM5:Reactive B-cell rich lymphoid proliferations that can mimic lymphoma Page Status: Incomplete
   - HAEM5:IgG4-related disease Page Status: Incomplete
   - HAEM5:Unicentric Castleman disease Page Status: Incomplete
   - HAEM5:Idiopathic multicentric Castleman disease Page Status: Incomplete
   - HAEM5:KSHV/HHV8-associated multicentric Castleman disease Page Status: Incomplete

Precursor B-cell neoplasms
 B-lymphoblastic leukaemias/lymphomas
   - HAEM5:B-lymphoblastic leukaemia/lymphoma Page Status: Incomplete
   - HAEM5:B-lymphoblastic leukaemia/lymphoma with high hyperdiploidy Page Status: Incomplete
   - HAEM5:B-lymphoblastic leukaemia/lymphoma with hypodiploidy Page Status: Incomplete
   - HAEM5:B-lymphoblastic leukaemia/lymphoma with iAMP21 Page Status: Complete
   - ABL1 fusion Page Status: Incomplete
   - ABL1-like features Page Status: Incomplete
   - HAEM5:B lymphoblastic leukaemia/lymphoma with KMT2A rearrangement Page Status: Incomplete
   - RUNX1 fusion Page Status: Incomplete
   - RUNX1-like features Page Status: Incomplete
   - PBX1 fusion Page Status: Incomplete
   - IL3 fusion Page Status: Incomplete
   - HLF fusion Page Status: Incomplete
   - HAEM5:B-lymphoblastic leukaemia/lymphoma with other defined genetic alterations Page Status: Incomplete
   - HAEM5:B-lymphoblastic leukaemia/lymphoma, NOS Page Status: Incomplete

Mature B-cell neoplasms
 Pre-neoplastic and neoplastic small lymphocytic proliferations 
   - HAEM5:Monoclonal B-cell lymphocytosis Page Status: Incomplete
   - HAEM5:Chronic lymphocytic leukaemia/small lymphocytic lymphoma Page Status: Complete
 Splenic B-cell lymphomas and leukaemias
   - HAEM5:Hairy cell leukaemia Page Status: Incomplete
   - HAEM5:Splenic marginal zone lymphoma Page Status: Incomplete
   - HAEM5:Splenic diffuse red pulp small B-cell lymphoma Page Status: Incomplete
   - HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli Page Status: Incomplete
 Lymphoplasmacytic lymphoma
   - HAEM5:Lymphoplasmacytic lymphoma Page Status: Incomplete
 Marginal zone lymphoma
   - HAEM5:Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue Page Status: Incomplete
   - HAEM5:Primary cutaneous marginal zone lymphoma  Page Status: Incomplete
   - HAEM5:Nodal marginal zone lymphoma Page Status: Incomplete
   - HAEM5:Paediatric nodal marginal zone lymphoma Page Status: Incomplete
 Follicular lymphoma
   - HAEM5:In situ follicular B-cell neoplasm Page Status: Incomplete
   - HAEM5:Follicular lymphoma Page Status: Incomplete
   - HAEM5:Paediatric-type follicular lymphoma Page Status: Incomplete
   - HAEM5:Duodenal-type follicular lymphoma Page Status: Incomplete
 Cutaneous follicle centre lymphoma
   - HAEM5:Primary cutaneous follicle centre lymphoma Page Status: Incomplete
 Mantle cell lymphoma
   - HAEM5:In situ mantle cell neoplasm Page Status: Incomplete
   - HAEM5:Mantle cell lymphoma Page Status: Incomplete
   - HAEM5:Leukaemic non-nodal mantle cell lymphoma Page Status: Incomplete
 Transformations of indolent B-cell lymphomas
   - HAEM5:Transformations of indolent B-cell lymphomas Page Status: Incomplete
 Large B-cell lymphomas
   - HAEM5:Diffuse large B-cell lymphoma, NOS Page Status: Incomplete
   - HAEM5:T-cell/histiocyte-rich large B-cell lymphoma Page Status: Incomplete
   - HAEM5:Diffuse large B-cell lymphoma / high grade B-cell lymphoma with MYC and BCL2 rearrangements Page Status: Incomplete
   - HAEM5:ALK-positive large B-cell lymphoma Page Status: Incomplete
   - HAEM5:Large B-cell lymphoma with IRF4 rearrangement Page Status: Incomplete
   - HAEM5:High grade B-cell lymphoma with 11q aberrations Page Status: Incomplete
   - HAEM5:Lymphomatoid granulomatosis Page Status: Incomplete
   - HAEM5:EBV-positive diffuse large B-cell lymphoma Page Status: Incomplete
   - HAEM5:Diffuse large B-cell lymphoma associated with chronic inflammation Page Status: Incomplete
   - HAEM5:Fibrin-associated large B-cell lymphoma Page Status: Incomplete
   - HAEM5:Fluid overload-associated large B-cell lymphoma Page Status: Incomplete
   - HAEM5:Plasmablastic lymphoma Page Status: Incomplete
   - HAEM5:Primary large B-cell lymphoma of immune-privileged sites Page Status: Incomplete
   - HAEM5:Primary cutaneous diffuse large B-cell lymphoma, leg type Page Status: Incomplete
   - HAEM5:Intravascular large B-cell lymphoma Page Status: Incomplete
   - HAEM5:Primary mediastinal large B-cell lymphoma Page Status: Incomplete
   - HAEM5:Mediastinal grey zone lymphoma Page Status: Incomplete
   - HAEM5:High-grade B-cell lymphoma, NOS Page Status: Incomplete
 Burkitt lymphoma
   - HAEM5:Burkitt lymphoma Page Status: Incomplete
 KSHV/HHV8-associated B-cell lymphoid proliferations and lymphomas
   - HAEM5:Primary effusion lymphoma Page Status: Incomplete
   - HAEM5:KSHV/HHV8-positive diffuse large B-cell lymphoma Page Status: Incomplete
   - HAEM5:KSHV/HHV8-positive germinotropic lymphoproliferative disorder Page Status: Incomplete
 Lymphoid proliferations and lymphomas associated with immune deficiency and dysregulation
   - HAEM5:Hyperplasias arising in immune deficiency/dysregulation Page Status: Incomplete
   - HAEM5:Polymorphic lymphoproliferative disorders arising in immune deficiency / dysregulation  Page Status: Incomplete
   - HAEM5:EBV-positive mucocutaneous ulcer Page Status: Incomplete
   - HAEM5:Lymphomas arising in immune deficiency / dysregulation  Page Status: Incomplete
   - HAEM5:Inborn error of immunity-associated lymphoid proliferations and lymphomas Page Status: Incomplete

Hodgkin lymphoma
   - HAEM5:Classic Hodgkin lymphoma  Page Status: Incomplete
   - HAEM5:Nodular lymphocyte predominant Hodgkin lymphoma Page Status: Incomplete

Plasma cell neoplasms and other diseases with paraproteins
 Monoclonal gammopathies
   - HAEM5:Cold agglutinin disease  Page Status: Incomplete
   - HAEM5:IgM monoclonal gammopathy of undetermined significance Page Status: Incomplete
   - HAEM5:Non-IgM monoclonal gammopathy of undetermined significance Page Status: Incomplete
   - HAEM5:Monoclonal gammopathy of renal significance Page Status: Incomplete
 Diseases with monoclonal immunoglobulin deposition
   - HAEM5:Immunoglobulin-related (AL) amyloidosis Page Status: Incomplete
   - HAEM5:Monoclonal immunoglobulin deposition disease Page Status: Incomplete
 Heavy chain diseases
   - HAEM5:Mu heavy chain disease Page Status: Incomplete
   - HAEM5:Gamma heavy chain disease Page Status: Incomplete
   - HAEM5:Alpha heavy chain disease Page Status: Incomplete
 Plasma cell neoplasms
   - HAEM5:Plasmacytoma Page Status: Incomplete
   - HAEM5:Plasma cell myeloma / multiple myeloma Page Status: Incomplete
   - HAEM5:Plasma cell neoplasms with associated paraneoplastic syndrome Page Status: Incomplete

T-cell and NK-cell lymphoid proliferations and lymphomas

Tumour-like lesions with T-cell predominance
   - HAEM5:Kikuchi-Fujimoto disease Page Status: Complete
   - HAEM5:Autoimmune lymphoproliferative syndrome Page Status: Incomplete
   - HAEM5:Indolent T-lymphoblastic proliferation Page Status: Incomplete

Precursor T-cell neoplasms
 T-lymphoblastic leukaemia / lymphoma
   - HAEM5:T-lymphoblastic leukaemia / lymphoma, NOS Page Status: Incomplete
   - HAEM5:Early T-precursor lymphoblastic leukaemia / lymphoma  Page Status: Incomplete

Mature T-cell and NK-cell neoplasms
 Mature T-cell and NK-cell leukaemias
   - HAEM5:T-prolymphocytic leukaemia Page Status: Complete
   - HAEM5:T-large granular lymphocytic leukaemia Page Status: Incomplete
   - HAEM5:NK-large granular lymphocytic leukaemia Page Status: Complete
   - HAEM5:Adult T-cell leukaemia/lymphoma Page Status: Incomplete
   - HAEM5:Sezary syndrome Page Status: Incomplete
   - HAEM5:Aggressive NK-cell leukaemia Page Status: Incomplete
 Primary cutaneous T-cell lymphoid proliferations and lymphomas
   - HAEM5:Primary cutaneous CD4-positive small or medium T-cell lymphoproliferative disorder Page Status: Incomplete
   - HAEM5:Primary cutaneous acral CD8-positive T-cell lymphoproliferative disorder Page Status: Complete
   - HAEM5:Mycosis fungoides Page Status: Incomplete
   - HAEM5:Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Lymphomatoid papulosis Page Status: Incomplete
   - HAEM5:Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Primary cutaneous anaplastic large cell lymphoma Page Status: Incomplete
   - HAEM5:Subcutaneous panniculitis-like T-cell lymphoma Page Status: Complete
   - HAEM5:Primary cutaneous gamma/delta T-cell lymphoma Page Status: Complete
   - HAEM5:Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma Page Status: Complete
   - HAEM5:Primary cutaneous peripheral T-cell lymphoma, NOS Page Status: Incomplete
 Intestinal T-cell and NK-cell lymphoid proliferations and lymphomas
   - HAEM5:Indolent T-cell lymphoma of the gastrointestinal tract Page Status: Incomplete
   - HAEM5:Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract Page Status: Incomplete
   - HAEM5:Enteropathy-associated T-cell lymphoma Page Status: Incomplete
   - HAEM5:Monomorphic epitheliotropic intestinal T-cell lymphoma Page Status: Incomplete
   - HAEM5:Intestinal T-cell lymphoma, NOS Page Status: Incomplete
 Hepatosplenic T-cell lymphoma
   - HAEM5:Hepatosplenic T-cell lymphoma Page Status: Complete
 Anaplastic large cell lymphoma
   - HAEM5:ALK-positive anaplastic large cell lymphoma Page Status: Incomplete
   - HAEM5:ALK-negative anaplastic large cell lymphoma Page Status: Incomplete
   - HAEM5:Breast implant-associated anaplastic large cell lymphoma Page Status: Incomplete
 Nodal T-follicular helper (TFH) cell lymphoma
   - HAEM5:Nodal TFH cell lymphoma, angioimmunoblastic-type Page Status: Incomplete
   - HAEM5:Nodal TFH cell lymphoma, follicular-type Page Status: Incomplete
   - HAEM5:Nodal TFH cell lymphoma, NOS Page Status: Incomplete
 Other peripheral T-cell lymphomas
   - HAEM5:Peripheral T-cell lymphoma, NOS Page Status: Incomplete
 EBV-positive NK-cell and T-cell lymphomas
   - HAEM5:EBV-positive nodal T- and NK-cell lymphoma Page Status: Incomplete
   - HAEM5:Extranodal NK/T-cell lymphoma Page Status: Complete
 EBV-positive T-cell and NK-cell lymphoid proliferations and lymphomas of childhood
   - HAEM5:Severe mosquito bite allergy Page Status: Incomplete
   - HAEM5:Hydroa vacciniforme lymphoproliferative disorder Page Status: Incomplete
   - HAEM5:Systemic chronic active EBV disease Page Status: Complete
   - HAEM5:Systemic EBV-positive T-cell lymphoma of childhood Page Status: Complete

Stroma-derived neoplasms of lymphoid tissues

Mesenchymal dendritic cell neoplasms
 Follicular dendritic cell neoplasms
   - HAEM5:Follicular dendritic cell sarcoma Page Status: Incomplete
   - HAEM5:EBV-positive inflammatory follicular dendritic cell sarcoma Page Status: Incomplete
   - HAEM5:Fibroblastic reticular cell tumour Page Status: Incomplete

Myofibroblastic tumours
 Myofibroblastic tumour
   - HAEM5:Intranodal palisaded myofibroblastoma Page Status: Incomplete

Spleen-specific vascular-stromal tumours
 Splenic vascular-stromal tumours
   - HAEM5:Littoral cell angioma Page Status: Incomplete
   - HAEM5:Splenic hamartoma Page Status: Incomplete
   - HAEM5:Sclerosing angiomatoid nodular transformation (SANT) of spleen Page Status: Incomplete

Genetic tumour syndromes

   - HAEM5:Fanconi anaemia Page Status: Incomplete
   - GTS5:Bloom syndrome (BLM) Page Status: Incomplete
   - HAEM5:Ataxia-telangiectasia syndrome Page Status: Incomplete
   - HAEM5:RASopathies Page Status: Incomplete